{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:08:00Z","timestamp":1761894480377},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5275,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a pair of monozygotic twins who are concordant for myasthenia gravis but discordant for systemic lupus erythematosus (SLE). SLE developed in twin 1 18 years post\u2010thymectomy and has been characterized by recurrent transverse myelitis and optic neuritis. Twin 2 remains well post\u2010thymectomy, except for a skin rash and persistent leukopenia. Both twins have developed autoimmune thyroid disease. We review genetic and environmental factors of importance in the pathogenesis of SLE and discuss the possible role of thymectomy in the etiology of the disease.<\/jats:p>","DOI":"10.1002\/art.1780340719","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:30Z","timestamp":1171496430000},"page":"916-919","source":"Crossref","is-referenced-by-count":33,"title":["A pair of monozygotic twins who are concordant for myasthenia gravis but became discordant for systemic lupus erythematosus post\u2010thymectomy"],"prefix":"10.1002","volume":"34","author":[{"given":"Fiona M.","family":"Grinlinton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora M.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamish H.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90261-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.1.23"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992288202101209"},{"key":"e_1_2_1_5_2","first-page":"85","article-title":"Auto\u2010immune aspects of myasthenia gravis","volume":"137","author":"Downes JM","year":"1966","journal-title":"Q J Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.1.45"},{"key":"e_1_2_1_7_2","volume-title":"Diseases of the spinal cord, Principles of Neurology","author":"Adams R","year":"1985"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0307-742X(21)00195-8","article-title":"The immunogenetics of SLE","volume":"8","author":"Walport MJ","year":"1982","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197809072991004"},{"key":"e_1_2_1_11_2","unstructured":"RobertsMW MinnelKE WoodfieldDG:HLA antigens in Cook Islanders Proceedings of the Second Asia and Oceania Histocompatibility Workshop Conference Stonnington Melbourne Australia 1981"},{"key":"e_1_2_1_12_2","first-page":"648","article-title":"The onset of disease in twins and siblings with systemic lupus erythematosus","volume":"11","author":"Kaplan D","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90456-2"},{"key":"e_1_2_1_14_2","first-page":"179","article-title":"Systemic lupus erythematosus following thymectomy for myasthenia gravis","volume":"16","author":"Petersen P","year":"1969","journal-title":"Dan Med Bull"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270616"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.3.662"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130402"},{"key":"e_1_2_1_18_2","first-page":"579","article-title":"Induction of autoimmunity in normal mice by thymectomy and administration of polyclonal B cell activators: association with contrasuppressor function","volume":"51","author":"Smith HR","year":"1983","journal-title":"Clin Exp Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:09:19Z","timestamp":1700759359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1002\/art.1780340719"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340719","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}