{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:58:21Z","timestamp":1789444701892,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5177,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured interleukin\u20106 (IL\u20106) levels in 70 serum samples obtained from 25 patients with systemic\u2010onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic\u2010onset JRA had significantly elevated serum IL\u20106 levels during active disease (mean \u00b1 SD 92.1 \u00b1 75.1 hybridoma growth factor units\/ml; <jats:italic>P<\/jats:italic> &lt; 0.00001 versus healthy age\u2010matched controls), but not during remission. Serum IL\u20106 levels correlated with the extent and severity of joint involvement (<jats:italic>P<\/jats:italic> &lt; 0.001) and with platelet counts (<jats:italic>P<\/jats:italic> &lt; 0.05). Our data suggest that IL\u20106 plays a significant role in the pathogenesis of systemic\u2010onset JRA.<\/jats:p>","DOI":"10.1002\/art.1780340912","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:53:21Z","timestamp":1171497201000},"page":"1158-1163","source":"Crossref","is-referenced-by-count":286,"title":["Correlation of Serum Interleukin\u20106 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis"],"prefix":"10.1002","volume":"34","author":[{"given":"Fabrizio","family":"de Benedetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Robbioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Ravelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe R.","family":"Burgio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Textbook of Pediatric Rheumatology","author":"Cassidy JT","year":"1990"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-6153-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.001345"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114559"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113921"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.4049\/jimmunol.143.7.2153","article-title":"IL\u20106\/IFN\u2010\u03b22 in synovial effusion of patients with rheumatoid arthritis and other arthritides: identification of several isoforms and studies of cellular sources","volume":"143","author":"Bhardwaj N","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4049\/jimmunol.144.2.499","article-title":"IL\u20106 production by human articular chondrocytes: modulation of its synthesis by cytokines, growth factors and hormones in vitro","volume":"144","author":"Guerne PA","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310614"},{"key":"e_1_2_1_10_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830181010"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02201024"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.3.259"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748709102914"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T15:44:46Z","timestamp":1700754286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10,7]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1991,10,7]]}},"alternative-id":["10.1002\/art.1780340912"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340912","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10,7]]}}}