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Acetaminophen and ketoprofen had no effect; sodium salicylate, indomethacin, and diclofenac slightly decreased proteoglycanase activity. Piroxicam and tenoxicam suppressed proteoglycanase activity by 48.2% and 68.3%, respectively, and suppressed collagenase activity by 19.1% and 36.8%, respectively. Use of these NSAIDs may help to decrease cartilage catabolism in patients with OA.<\/jats:p>","DOI":"10.1002\/art.1780341021","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:44:47Z","timestamp":1171496687000},"page":"1332-1335","source":"Crossref","is-referenced-by-count":39,"title":["In Vitro Effect of Nonsteroidal Antiinflammatory Drugs on Proteoglycanase and Collagenase Activity in Human Osteoarthritic Cartilage"],"prefix":"10.1002","volume":"34","author":[{"given":"Eric","family":"Vignon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Louisot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90651-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90848-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230908"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.6.487"},{"issue":"1","key":"e_1_2_1_6_2","first-page":"30","article-title":"Laboratory evaluation of anti\u2010arthritic drugs as potential chondroprotective agents","volume":"17","author":"Burkhardt D","year":"1987","journal-title":"Semin Arthritis Rheum"},{"key":"e_1_2_1_7_2","first-page":"1014","article-title":"The in vitro effect of select classes of nonsteroidal anti\u2010inflammatory drugs on normal cartilage metabolism","volume":"13","author":"Herman JH","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","first-page":"646","article-title":"In vitro effect of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage","volume":"16","author":"Pelletier JP","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198800351-00008"},{"issue":"18","key":"e_1_2_1_10_2","first-page":"35","article-title":"Phospholipase A2 activity in human osteoarthritic cartilage","volume":"16","author":"Vignon E","year":"1988","journal-title":"J Rheumatol"},{"issue":"1","key":"e_1_2_1_11_2","first-page":"1","article-title":"Cartilage degradative enzymes in human osteoarthritis: effect of a nonsteroidal anti\u2010inflammatory drug administered orally","volume":"19","author":"Vignon E","year":"1990","journal-title":"Semin Arthritis Rheum"},{"key":"e_1_2_1_12_2","volume-title":"Multiple comparisons, Biostatistical Analysis","author":"Zar JH","year":"1974"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2480265"},{"key":"e_1_2_1_14_2","first-page":"751","article-title":"Some nonsteroidal anti\u2010inflammatory drugs inhibit the generation of superoxide anions by activated polymorphs by blocking ligandreceptor interactions","volume":"12","author":"Minta JO","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320102"},{"key":"e_1_2_1_16_2","first-page":"17","volume-title":"Tenoxicam distribution in articular tissues, XVIIth International League Against Rheumatism Congress of Rheumatology","author":"Bannwarth B","year":"1989"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780341021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780341021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T22:53:44Z","timestamp":1700693624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780341021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,10,10]]}},"alternative-id":["10.1002\/art.1780341021"],"URL":"https:\/\/doi.org\/10.1002\/art.1780341021","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10,10]]}}}