{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:46Z","timestamp":1791300526127,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T00:00:00Z","timestamp":1281916800000},"content-version":"vor","delay-in-days":6863,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In idiopathic inflammatory myopathy (IIM; or, polymyositis\/dermatomyositis), the myositis\u2010specific autoantibodies anti\u2010Jo\u20101 and anti\u2010signal recognition particle (anti\u2010SRP), appear to define clinically and immunogenetically distinct groups of patients. We show here that the month during which the onset of weakness occurs is not random in patients with anti\u2010Jo\u20101 autoantibodies (average month April, <jats:italic>P<\/jats:italic> &lt; 0.02) and in those with anti\u2010SRP autoantibodies (average month November, <jats:italic>P<\/jats:italic> &lt; 0.02); both groups of patients also experience rapid onset of disease. By contrast, patients classified into the traditional categories of polymyositis and dermatomyositis do not have recognizable seasonal patterns and do not differ in the rate of onset of disease. These findings suggest that searches for seasonal patterns in the onset of autoimmune disorders characterized by disease\u2010specific autoantibodies may provide useful clues to etiology.<\/jats:p>","DOI":"10.1002\/art.1780341108","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T01:46:50Z","timestamp":1282009610000},"page":"1391-1396","source":"Crossref","is-referenced-by-count":97,"title":["Distinct seasonal patterns in the onset of adult idiopathic inflammatory myopathy in patients with anti\u2010jo\u20101 and anti\u2010signal recognition particle autoantibodies"],"prefix":"10.1002","volume":"34","author":[{"given":"Richard L.","family":"Leff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne H.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira N.","family":"Targoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinos C.","family":"Dalakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall M.","family":"Joffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Plotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197503202921203"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291109"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92271-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.5.310"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80006-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110192"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/304177a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90740-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271011"},{"key":"e_1_2_1_12_2","first-page":"663","article-title":"Antibody to Jo\u20101 in polymyositis\/dermatomyositis: association with interstitial pulmonary disease","volume":"11","author":"Hochberg MC","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(86)90014-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-2-143"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330908"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.4049\/jimmunol.144.5.1737","article-title":"Autoantibodies to aminoacyl\u2010transfer RNA synthetases for isoleucine and glycine: two additional synthetases are antigenic in myositis","volume":"144","author":"Targoff IN","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","volume-title":"Circular statistics in biology, Mathematics in Biology","author":"Batschelet E","year":"1981"},{"key":"e_1_2_1_19_2","volume-title":"Statistics, SAS User's Guide","author":"SAS Institute","year":"1985"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780341108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780341108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:15:43Z","timestamp":1700694943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780341108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1002\/art.1780341108"],"URL":"https:\/\/doi.org\/10.1002\/art.1780341108","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]}}}