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These patients had 1.5\u20134\u2010fold more lymphocytes secreting IgG and IgM per million peripheral blood lymphocytes than did normal controls. There was a concomitant increase in the number of B cells secreting antibodies reactive with a diverse panel of foreign and self antigens (including actin, myosin, trinitrophenylated keyhole limpet hemocyanin, ovalbumin, and retroviral gp160). By comparison, the number of B cells producing anti\u2010DNA antibodies was increased disproportionately. The magnitude of this anti\u2010DNA response correlated significantly with disease activity. 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