{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:12:29Z","timestamp":1791151949892,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T00:00:00Z","timestamp":1282780800000},"content-version":"vor","delay-in-days":6843,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anterior cruciate ligament transection (ACLT) in the dog results in osteophyte formation and in morphologic, metabolic, biochemical, and biomechanical changes in the articular cartilage of the unstable knee that mimic those of human osteoarthritis (OA). However, in dogs studied up to 2 years after ACLT, the changes have appeared to be self\u2010limiting, which has led to the suggestion that this is a model of cartilage damage and repair, rather than of OA. To ascertain whether changes in articular cartilage and subchondral bone of dogs subjected to ACLT lead to progressive changes of OA, we studied 3 dogs for 54 months after ACLT. Arthrotomy was performed in the dogs to visualize and then transect the anterior cruciate ligament. When the dogs were killed, full\u2010thickness ulceration of the articular cartilage was seen on the medial femoral condyle and tibial plateau of the unstable knee, while cartilage in other regions was thicker than that of the contralateral knee, consistent with hypertrophic cartilage repair.<\/jats:p><jats:p>Synovial infiltration by mononuclear cells was not more severe than that seen in dogs killed at earlier intervals after ACLT, although gross fibrotic thickening of the capsule was apparent in each dog. Histomorphometric studies revealed a marked increase in subchondral bone volume and active bone formation. These findings show that the changes that develop in the canine knee joint after ACLT are progressive and are unambiguously those of OA.<\/jats:p>","DOI":"10.1002\/art.1780341214","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T08:04:25Z","timestamp":1284019465000},"page":"1560-1570","source":"Crossref","is-referenced-by-count":276,"title":["Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty\u2010four months after transection of the anterior cruciate ligament"],"prefix":"10.1002","volume":"34","author":[{"given":"Kenneth D.","family":"Brandt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260808"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1302\/0301-620X.59B1.576611","article-title":"An experimental model of osteoarthritis: early morphological and biochemical changes","volume":"59","author":"McDevitt C","year":"1977","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_4_2","first-page":"231","article-title":"Changes in the tensile and compressive properties of articular cartilage in a canine model of osteoarthritis","volume":"11","author":"Myers ER","year":"1986","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197153080-00008"},{"key":"e_1_2_1_6_2","first-page":"428","article-title":"Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection","volume":"18","author":"Adams ME","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320913"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251009"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193086"},{"key":"e_1_2_1_10_2","first-page":"818","article-title":"Cartilage hypertrophy following canine anterior cruciate ligament transection differs among different areas of the joint","volume":"16","author":"Adams ME","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(90)90081-P"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/10520296409061213"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330913"},{"key":"e_1_2_1_14_2","volume-title":"Statistics: An Intuitive Approach","author":"Weinberg GH","year":"1974"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100010402"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90690-0"},{"key":"e_1_2_1_17_2","volume-title":"The pathology of osteoarthritis, Osteoarthritis: Diagnosis and Management","author":"Meachim G","year":"1984"},{"key":"e_1_2_1_18_2","volume-title":"Clinical features of osteoarthritis, Textbook of Rheumatology","author":"Mankin HJ","year":"1989"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.1.82"},{"key":"e_1_2_1_20_2","first-page":"1098","article-title":"Spontaneous arthritis in Rhesus macaques. I. Chemical and biochemical studies","volume":"16","author":"Ch\u01ceteauvert J","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_21_2","first-page":"73","article-title":"Spontaneous arthritis in Rhesus macaques. II. Characterization of disease and morphometric studies","volume":"17","author":"Ch\u01ceteauvert J","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700440119"},{"key":"e_1_2_1_23_2","first-page":"1223","article-title":"Kinetics of osteoarthritis","volume":"8","author":"Johnson LC","year":"1959","journal-title":"Lab Invest"},{"issue":"9","key":"e_1_2_1_24_2","first-page":"S91","article-title":"Subchondral plate and trabecular bone in experimentally\u2010induced osteoarthritis (abstract)","volume":"33","author":"Dedrick DK","year":"1990","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197107000-00031"},{"key":"e_1_2_1_26_2","volume-title":"Mechanical factors influencing cartilage damage. Osteoarthrosis: Current Clinical and Fundamental Problems","author":"Radin EL","year":"1986"},{"key":"e_1_2_1_27_2","unstructured":"MyersSL BrandtKDO'ConnorBL:\u201cLow\u2010dose\u201d corticosteroid treatment does not reduce the severity of osteoarthritis in dogs after anterior cruciate ligament transection. J Rheumatol (in press)"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780341214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780341214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T20:30:59Z","timestamp":1700685059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780341214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1002\/art.1780341214"],"URL":"https:\/\/doi.org\/10.1002\/art.1780341214","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}