{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:58:12Z","timestamp":1759939092835},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T00:00:00Z","timestamp":1282780800000},"content-version":"vor","delay-in-days":6843,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a 16\u2010year\u2010old girl with systemic\u2010onset juvenile arthritis who presented with pulmonary hypertension, without evidence of pleural or parenchymal involvement of the lung, pulmonary vasculitis, or immune deposition in the pulmonary vasculature. Pleuropulmonary involvement occurs occasionally in juvenile arthritis, but primary pulmonary hypertension has not, to our knowledge, been previously reported. Histocompatibility typing showed positivity for HLA\u2010DR3 and DRw52, both of which are associated with idiopathic pulmonary hypertension in children, and with pulmonary hypertension among patients with systemic sclerosis. Treatment with cyclosporine and corticosteroids resulted in a marked improvement in the clinical findings and pulmonary function in our patient.<\/jats:p>","DOI":"10.1002\/art.1780341216","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T08:04:25Z","timestamp":1284019465000},"page":"1575-1579","source":"Crossref","is-referenced-by-count":29,"title":["Primary pulmonary hypertension in a patient with systemic\u2010onset juvenile arthritis"],"prefix":"10.1002","volume":"34","author":[{"given":"Shai","family":"Padeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M.","family":"Laxer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith M.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl D.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(76)90027-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80085-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0272-5231(21)00087-3","article-title":"Pulmonary manifestation of juvenile rheumatoid arthritis","volume":"1","author":"Athreya BH","year":"1980","journal-title":"Clin Chest Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80972-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(90)90037-6"},{"key":"e_1_2_1_7_2","first-page":"416","article-title":"Pulmonary hypertension in systemic lupus erythematosus: a report of three cases","volume":"13","author":"Asherson RA","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011462"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb07290.x"},{"key":"e_1_2_1_10_2","volume-title":"Primary Pulmonary Hypertension: Report on a WHO Meeting","author":"Hatano S","year":"1975"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198601000-00004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.5.1198"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90091-0"},{"issue":"9","key":"e_1_2_1_15_2","first-page":"S120","article-title":"Immunogenetic studies of childhood pulmonary hypertension (abstract)","volume":"33","author":"Barst RJ","year":"1990","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80413-8"},{"issue":"9","key":"e_1_2_1_17_2","first-page":"S157","article-title":"HLA alleles in systemic sclerosis: association with pulmonary hypertension and outcome (abstract)","volume":"33","author":"Gladman DD","year":"1990","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(77)90078-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280304"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.5.1207"},{"key":"e_1_2_1_21_2","first-page":"1292","article-title":"Pulmonary hypertension in a lupus clinic: experience with twenty\u2010four patients","volume":"17","author":"Asherson RA","year":"1990","journal-title":"J Rheumatol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780341216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780341216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T20:32:14Z","timestamp":1700685134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780341216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1002\/art.1780341216"],"URL":"https:\/\/doi.org\/10.1002\/art.1780341216","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}