{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:21Z","timestamp":1761512361210},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5091,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To characterize the mechanism(s) by which 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> (calcitriol) modulates the costimulatory capacity of monocytes, we examined the effect of calcitriol pretreatment of monocytes on their capacity to promote T cell proliferation (accessory cell function). Correlation of calcitriol\u2010dependent changes in monocyte accessory cell function and alterations in phenotype and cytokine production, and the dependence of these changes on cell viability, were studied. Calcitriol pretreatment induced a defect in accessory cell function that was evident with fixed monocytes, suggesting a cell\u2010surface\u2014associated mechanism. Altered accessory cell function did not correlate with changes in HLA\u2014DR antigen expression and was unaffected by concurrent treatment with interferon\u2010\u03b3. Calcitriol treatment did not alter either the expression of adhesion molecules or monocytic production of interleukin\u20101\u03b2 (IL\u20101\u03b2) or IL\u20106. Exogenous IL\u20101 or IL\u20106 did not overcome the impaired costimulatory activity of calcitriol\u2010treated monocytes. Thus, calcitriol treatment reduces the capacity of monocytes to promote lectin\u2010induced T cell activation at the level of the plasma membrane, perhaps through altered expression of an uncharacterized molecule important in monocyte\u2014T cell interactions. At chronically inflamed sites, elaboration of calcitriol by activated macrophages may regulate the ability of monocytes to induce both antigen\u2010dependent and antigen\u2010independent T cell proliferation.<\/jats:p>","DOI":"10.1002\/art.1780350117","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:49:17Z","timestamp":1171496957000},"page":"110-119","source":"Crossref","is-referenced-by-count":38,"title":["Decreased Accessory Cell Function and Costimulatory Activity BY 1, 25\u2010Dihydroxyvitamin D<sub>3<\/sub>\u2014Treated Monocytes"],"prefix":"10.1002","volume":"35","author":[{"given":"WILLIAM F. 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