{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:42:21Z","timestamp":1780472541194,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5060,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1992,2]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To investigate the association between CD5+ B cell expression and IgM rheumatoid factor (IgM\u2010RF) in juvenile rheumatoid arthritis (JRA).<\/jats:p>Methods.<\/jats:italic> CD5+ B cell levels analyzed by flow cytometry and IgM\u2010RF expression determined by enzymelinked immunosorbent assay were compared in children with JRA, children with other collagen vascular diseases, and healthy controls.<\/jats:p>Results.<\/jats:italic> Children with polyarticular JRA had expanded populations of CD5+ B cells, and expansion of CD5+ B cells and IgM\u2010RF both correlated with disease activity.<\/jats:p>Conclusion.<\/jats:italic> The results indicate that an expanded CD5+ B cell population leads to IgM\u2010RF production in patients with polyarticular JRA, as well as patients with RA.<\/jats:p>","DOI":"10.1002\/art.1780350213","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:47:17Z","timestamp":1171496837000},"page":"204-207","source":"Crossref","is-referenced-by-count":17,"title":["Increase in CD5+ B Cells in Juvenile Rheumatoid Arthritis"],"prefix":"10.1002","volume":"35","author":[{"given":"James 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