{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:55Z","timestamp":1760188855301},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5031,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1992,3]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To investigate the relationship between L\u2010tryptophan (LT) ingestion and eosinophilic fasciitis (EF) occurring prior to the outbreak of eosinophiliamyalgia syndrome in 1989.<\/jats:p>Methods.<\/jats:italic> Interviews and record reviews of 45 EF case\u2010patients and 126 polymyositis patients (controls) diagnosed prior to 1988.<\/jats:p>Results.<\/jats:italic> Nine case\u2010patients (20%) and no controls recalled taking LT before onset of the disease (odds ratio = \u221e, 95% confidence interval = 8.3\u2013\u221e). Among EF case\u2010patients, LT ingestion was associated with dyspnea.<\/jats:p>Conclusion.<\/jats:italic> LT ingestion was associated with EF prior to the 1989 outbreak of eosinophilia\u2010myalgia syndrome. Lung abnormalities may be a distinguishing feature of LT\u2010mediated illness.<\/jats:p>","DOI":"10.1002\/art.1780350308","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:46:41Z","timestamp":1171496801000},"page":"299-303","source":"Crossref","is-referenced-by-count":18,"title":["L\u2010tryptophan\u2014associated eosinophilic fasciitis prior to the 1989 eosinophilia\u2014Myalgia syndrome outbreak"],"prefix":"10.1002","volume":"35","author":[{"given":"Jonathan R.","family":"Hibbs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Mittleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"70","article-title":"Diffuse fasciitis with eosinophilia: a new syndrome","volume":"88","author":"Shulman LE","year":"1975","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_2_1_2_2","first-page":"765","article-title":"Eosinophilia\u2010myalgia syndrome: New Mexico","volume":"38","author":"CDC","year":"1989","journal-title":"MMWR"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450130070029"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-2-124"},{"key":"e_1_2_1_5_2","first-page":"789","article-title":"Update: analysis of L\u2010tryptophan for the etiology of eosinophilia\u2010myalgia syndrome","volume":"39","author":"CDC","year":"1990","journal-title":"MMWR"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220913"},{"key":"e_1_2_1_7_2","volume-title":"Dictionary of the Rheumatic Diseases","author":"American Rheumatism Association Glossary Committee","year":"1982"},{"key":"e_1_2_1_8_2","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1958","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_9_2","volume-title":"Nonparametric statistics for the behavioral sciences","author":"Siegel S","year":"1956"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(75)90048-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-10-758"},{"key":"e_1_2_1_12_2","first-page":"259","article-title":"Eosinophilic fasciitis is clinically distinguishable from the eosinophilia\u2010myalgia syndrome and is not associated with L\u2010tryptophan use","volume":"18","author":"Varga J","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","first-page":"247","article-title":"Review of interstitial pneumonia in cattle","volume":"31","author":"Kerr LA","year":"1989","journal-title":"Vet Hum Toxicol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008093230601"},{"key":"e_1_2_1_15_2","first-page":"589","article-title":"Analysis of L\u2010tryptophan for the etiology of eosinophilia\u2010myalgia syndrome","volume":"39","author":"CDC","year":"1990","journal-title":"MMWR"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780350308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780350308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T03:30:52Z","timestamp":1700710252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780350308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1002\/art.1780350308"],"URL":"https:\/\/doi.org\/10.1002\/art.1780350308","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}