{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:28Z","timestamp":1788872428062,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4970,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["5647"],"award-info":[{"award-number":["5647"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Association Against Rheumatism"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1992,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective.<\/jats:italic>\n We describe a dysfunction of C3 in a patient with a systemic lupus erythematosus (SLE)\u2010like syndrome. Alternative pathway complement function was absent, but classical pathway complement function was partially intact.\n <\/jats:p>\n \n Methods.<\/jats:italic>\n We used functional, preparative, and immunochemical techniques in the study.\n <\/jats:p>\n \n Results.<\/jats:italic>\n The patient's C3 proved normally susceptible to trypsin proteolysis and partially resistant to classical pathway, but completely resistant to alternative pathway, convertase\u2010dependent cleavage.\n <\/jats:p>\n \n Conclusion.<\/jats:italic>\n The dysfunction, thus, was caused by a failure of C3 to interact with the C3 convertases, rather than by a lack of a proteinase\u2010sensitive cleavage site in the deficient protein.\n <\/jats:p>","DOI":"10.1002\/art.1780350516","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T18:39:59Z","timestamp":1173379199000},"page":"580-586","source":"Crossref","is-referenced-by-count":19,"title":["Hereditary dysfunction of the third component of complement associated with a systemic lupus erythematosus\u2010like syndrome and meningococcal meningitis"],"prefix":"10.1002","volume":"35","author":[{"given":"Ulf R.","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Erik","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Sj\u00f6lin\u2010Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"H\u00e4llgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198409000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90067-X"},{"key":"e_1_2_1_4_2","first-page":"486","article-title":"The role of complement 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vitro phosphorylation of human complement factor C3 by protein kinase A and protein kinase C","volume":"265","author":"Forsberg PO","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.4049\/jimmunol.112.3.1164","article-title":"A functional abnormality of the fifth component of complement (C5) from human serum of individuals with a familial opsonic defect","volume":"112","author":"Nilsson UR","year":"1974","journal-title":"J Immunol"},{"key":"e_1_2_1_20_2","first-page":"387","article-title":"Inhibition of immune precipitation by complement","volume":"42","author":"Schifferli JA","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.2.418"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105904"},{"key":"e_1_2_1_23_2","volume-title":"The role of complement in the processing of immune complexes, Complement and 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