{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:14:45Z","timestamp":1767960885481,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4939,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1992,6]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To determine the clinical and serologic risk factors for digital ischemic events in patients with systemic sclerosis (SSc).<\/jats:p>Methods.<\/jats:italic> Retrospective review of clinical and laboratory data and review of current clinical status of 98 patients with SSc, seen between 1985 and 1990.<\/jats:p>Results.<\/jats:italic> Amputation of 1 or more digits due to ischemia occurred in 20.4% of the patients; 9.2% had multiple digit loss. Sclerodactyly alone and anticentromere antibody (ACA) were associated with loss of 1 or more digits. Age, smoking status, duration of disease, or duration of Raynaud's phenomenon were not predictive for loss of digits.<\/jats:p>Conclusion.<\/jats:italic> Patients with limited SSc who are positive for ACA have an increased risk of major peripheral vascular occlusive disease.<\/jats:p>","DOI":"10.1002\/art.1780350614","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:16:01Z","timestamp":1171498561000},"page":"688-693","source":"Crossref","is-referenced-by-count":136,"title":["Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis"],"prefix":"10.1002","volume":"35","author":[{"given":"Fredrick M.","family":"Wigley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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