{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:19:04Z","timestamp":1790054344128,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4878,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1992,8]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> We sought to determine whether circulating antikeratin antibodies (AKA) precede the onset of rheumatoid arthritis (RA).<\/jats:p>Methods.<\/jats:italic> By matching the registers of 2 previous population studies with the registry of patients receiving antirheumatic drugs several years later, pre\u2010illness serum specimens could be obtained from 39 individuals who subsequently developed RA. AKA were assayed with the standard indirect immunofluorescence technique.<\/jats:p>Results.<\/jats:italic> Ten of 39 serum specimens from individuals who subsequently developed seropositive RA, and 1 of 15 sera from individuals who developed seronegative RA, were positive for IgG\u2010class AKA by immunofluorescence assay. The AKA\u2010positive sera were also positive for rheumatoid factors.<\/jats:p>Conclusion.<\/jats:italic> The findings focus attention on the role of pre\u2010illness immunologic events in the pathogenesis of RA.<\/jats:p>","DOI":"10.1002\/art.1780350810","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:12:16Z","timestamp":1171498336000},"page":"914-917","source":"Crossref","is-referenced-by-count":94,"title":["Immunopathology of rheumatoid arthritis"],"prefix":"10.1002","volume":"35","author":[{"given":"Pekka","family":"Kurki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo","family":"Aho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Palosuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Heli\u00f6vaara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.1.1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(197607\/08)19:4<711::AID-ART1780190409>3.0.CO;2-I"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00271874"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321204"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310120"},{"issue":"9","key":"e_1_2_1_7_2","first-page":"S96","article-title":"Characterization of two new antigen\u2013antibody systems (SA\/TA) in patients with rheumatoid arthritis (abstract)","volume":"33","author":"Despr\u00e9s N","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"5","key":"e_1_2_1_8_2","first-page":"89","article-title":"IgG and rheumatoid factor at a glance","volume":"8","author":"Roitt IM","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90352-6"},{"key":"e_1_2_1_10_2","first-page":"874","article-title":"The clinical significance of immune reactions with some streptococcal antigens in rheumatoid arthritis","volume":"17","author":"Zborovsky A","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330319"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6182.97"},{"key":"e_1_2_1_13_2","first-page":"602","article-title":"Diagnostic value of antikeratin antibodies in rheumatoid 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