{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:34:52Z","timestamp":1760027692797},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4878,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To analyze the anti\u2013Ro\/SS\u2010A and anti\u2013La\/SS\u2010B autoantibody responses, both quantitatively and qualitatively, in relation to the occurrence of congenital heart block (CHB) and disease activity in a patient with systemic lupus erythematosus.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> The patient's course was carefully documented for a period of 80 months. Specific enzyme\u2010linked immunosorbent assays, a HeLa cell immunoblotting test, and an RNA precipitation assay were used to determine autoantibody levels and fine specificities.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Anti\u2013Ro\/SS\u2010A and anti\u2013La\/SS\u2010B antibody did not disappear. Levels of anti\u2013Ro\/SS\u2010A appeared to fluctuate more frequently than levels of anti\u2013La\/SS\u2010B. Fluctuations were unrelated to disease activity or immunosuppressive treatment. There was no characteristic relationship between levels of these antibodies and the occurrence of CHB.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The occurrence of CHB cannot be predicted by frequent measurement of anti\u2013Ro\/SS\u2010A and anti\u2013La\/SS\u2010B levels. The immunoregulatory control of anti\u2013Ro\/SS\u2010A and anti\u2013La\/SS\u2010B antibodies differs from that of anti\u2010DNA and anti\u2013tetanus toxoid antibodies.<\/jats:p>","DOI":"10.1002\/art.1780350817","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:12:16Z","timestamp":1171498336000},"page":"953-959","source":"Crossref","is-referenced-by-count":38,"title":["Anti\u2013Ro\/SS\u2010A and Anti\u2013La\/SS\u2010B autoantibody levels in relation to systemic lupus erythematosus disease activity and congenital heart block"],"prefix":"10.1002","volume":"35","author":[{"given":"Ronald H. W. M.","family":"Derksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F.","family":"Meilof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307283090403"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198411000-00003"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501103120206"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198609113151103"},{"key":"e_1_2_1_6_2","first-page":"169","article-title":"The neonatal lupus syndrome","volume":"6","author":"Maddison PJ","year":"1988","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281202"},{"key":"e_1_2_1_8_2","first-page":"120","article-title":"Importance of the immune response to the Ro\/La particle in the development of congenital heart block and neonatal lupus erythematosus","volume":"18","author":"Silverman E","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291013"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310601"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90362-Y"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300602"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114208"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114467"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276566"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02099027"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90368-N"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780350817","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780350817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T02:55:47Z","timestamp":1700708147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780350817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1002\/art.1780350817"],"URL":"https:\/\/doi.org\/10.1002\/art.1780350817","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8]]}}}