{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:20:19Z","timestamp":1771665619493,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":5706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To investigate whether soluble interleukin\u20102 receptor (sIL\u20102R), a marker of T cell activation, could be a useful marker of disease activity in Wegener's granulomatosis (WG).<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Soluble IL\u20102R levels were determined by enzyme\u2010linked immunosorbent assay. WG disease activity in 102 patients was assessed according to clinical features and levels of classic antineutrophil cytoplasmic antibody (c\u2010ANCA) and C\u2010reactive protein (CRP).<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Soluble IL\u20102R levels were higher in patients with generalized and active disease than in those with limited and inactive disease. In 25 patients with complete clinical remission, sIL\u20102R levels were significantly elevated, although levels of CRP and c\u2010ANCA were normal. Eight of these 25 patients had disease relapses within 6 months. Levels of sIL\u20102R were significantly higher in patients who had relapses than in those who did not. Patients with clinically active WG but low c\u2010ANCA or CRP levels had elevated levels of sIL\u20102R.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Levels of sIL\u20102R correlate with disease activity in patients with WG, and may indicate imminent relapse.<\/jats:p>","DOI":"10.1002\/art.1780350914","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:10:14Z","timestamp":1171498214000},"page":"1088-1096","source":"Crossref","is-referenced-by-count":109,"title":["Elevated serum levels of soluble interleukin\u20102 receptor in patients with Wegener's granulomatosis. 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