{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:57:49Z","timestamp":1770699469167,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":5676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> In vitro studies have indicated that levels of neutral metalloproteinases in osteoarthritic (OA) cartilage are elevated and that doxycycline (doxy) inhibits collagenolytic and gelatinolytic activity in extracts of OA cartilage. The purpose of the present study was to test the effect of oral doxy administration on the severity of cartilage degeneration in OA.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> OA was induced in 12 adult mongrel dogs by transection of the anterior cruciate ligament (ACL) 2 weeks after dorsal root ganglionectomy. Six dogs received doxy orally from the day after ACL transection until they were killed 8 weeks later; the other 6 served as untreated OA controls.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> The unstable knee of each untreated dog exhibited extensive full\u2010thickness cartilage ulceration of the medial femoral condyle. In sharp contrast, cartilage on the distal aspect of the femoral condyle of the unstable knee was grossly normal in 2 doxy\u2010treated dogs, and exhibited only thinning and\/or surface irregularity in the others. Degenerative cartilage lesions on the medial trochlear ridge, superficial fibrillation of the medial tibial plateau, and osteophytosis were, however, unaffected by doxy treatment. Collagenolytic activity and gelatinolytic activity in cartilage extracts from OA knees of untreated dogs were 5\u2010fold and 4\u2010fold greater, respectively, than in extracts from dogs given doxy.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Prophylactic administration of doxy markedly reduced the severity of OA in weight\u2010bearing regions of the medial femoral condyle. It remains to be determined whether administration of doxy after OA changes have developed is also effective.<\/jats:p>","DOI":"10.1002\/art.1780351007","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:48:31Z","timestamp":1171496911000},"page":"1150-1159","source":"Crossref","is-referenced-by-count":185,"title":["Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline"],"prefix":"10.1002","volume":"35","author":[{"suffix":"Jr.","given":"Lucino P.","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Gerald N.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen 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