{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:18:30Z","timestamp":1761743910502},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":7885,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1992,11]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To determine causes of death, estrogen toxicity, and hyperprolactinemia in a murine model of systemic lupus erythematosus (SLE).<\/jats:p>Methods<\/jats:italic>. Female New Zealand Black \u00d7 New Zealand White (NZB \u00d7 NZW) mice were implanted with ethinyl estradiol, 17 beta\u2014estradiol, or empty capsules (controls).<\/jats:p>Results<\/jats:italic>. Estrogen\u2010treated mice developed striking hyperprolactinemia and died prematurely with genitourinary complications.<\/jats:p>Conclusion<\/jats:italic>. Implanted estrogens, including 17 beta\u2014estradiol in a dose reported previously to stimulate SLE, contribute to premature death in NZB \u00d7 NZW mice, through toxic effects. Estrogen therapy increases the level of prolactin, an immunostimulatory hormone.<\/jats:p>","DOI":"10.1002\/art.1780351123","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T10:48:48Z","timestamp":1401878928000},"page":"1387-1392","source":"Crossref","is-referenced-by-count":39,"title":["Premature death with bladder outlet obstruction and hyperprolactinemia in new zealand black \u00d7 new zealand white mice treated with ethinyl estradiol and 17 beta\u2014estradiol"],"prefix":"10.1002","volume":"35","author":[{"given":"Sara E.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia L.","family":"Besch\u2010Williford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duane H.","family":"Keisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Systemic lupus erythematosus: clinical aspects and treatment, Arthritis and Allied Conditions. 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