{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:55Z","timestamp":1760188855741},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":5615,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To evaluate the extent to which seemingly healthy, mature adults with mild symptoms of dry eyes or dry mouth share the immunologic features found in patients with Sj\u00f6gren's syndrome.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Of 705 subjects in Malm\u00f6, Sweden (age range 52\u201372 years) who responded to a questionnaire, 35% reported some symptoms of dry eyes or mouth. A random subgroup of the symptomatic subjects (n = 77) and an age\u2010 and sex\u2010matched control group from among the asymptomatic subjects (n = 32) were evaluated objectively by serologic testing and by various measures of exocrine gland function.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> The symptomatic subjects had relatively impaired exocrine gland function and elevated levels of anti\u2010Ro and anti\u2010La (1.54\u20132.88\u2010fold increase compared with the asymptomatic subjects, 95% confidence interval [CI] 1.41, 4.03). The 2 autoantibodies correlated with each other (r = 0.64, 95% CI 0.49, 0.78) as well as with selected clinical measures of glandular function.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The association between self\u2010reported symptoms of dry eyes or dry mouth and anti\u2010Ro and anti\u2010La, found in more than one\u2010third of mature adults in this study, suggests that the immune abnormalities and exocrine gland dysfunction found in Sj\u00f6gren's syndrome affect a substantial proportion of the general population.<\/jats:p>","DOI":"10.1002\/art.1780351213","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:48:17Z","timestamp":1171496897000},"page":"1492-1501","source":"Crossref","is-referenced-by-count":24,"title":["Association of dry eyes and dry mouth with anti\u2014Ro\/SS\u2010A and anti\u2014La\/SS\u2010B Autoantibodies in normal 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