{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:08:35Z","timestamp":1788671315008,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1993,4]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc).<\/jats:p>Methods.<\/jats:italic> A retrospective chart review of 248 patients who were followed up prospectively was conducted.<\/jats:p>Results.<\/jats:italic> Cancers developed in 18 patients (7.3%) during 2,001 patient\u2010years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age\u2010standardized incidence rate for all cancers (7.9\/1,000) was 2.1 times the overall rate in the Ontario population (P<\/jats:italic> > 0.0001).<\/jats:p>Conclusion.<\/jats:italic> The frequency of cancer is increased in patients with SSc.<\/jats:p>","DOI":"10.1002\/art.1780360405","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:40:09Z","timestamp":1171500009000},"page":"460-464","source":"Crossref","is-referenced-by-count":156,"title":["Cancer in systemic sclerosis"],"prefix":"10.1002","volume":"36","author":[{"given":"Mahmoud","family":"Abu\u2010Shakra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Guillemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195311)6:6<1147::AID-CNCR2820060605>3.0.CO;2-L"},{"key":"e_1_2_1_3_2","first-page":"665","article-title":"Malignancy in progressive systemic sclerosis: association with breast carcinoma","volume":"10","author":"Lee P","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281204"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.782.1071"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1001\/archderm.1979.04010080014013","article-title":"Cancer and scleroderma","volume":"115","author":"Duncan SC","year":"1970","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250916"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580150005001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-41-5-1003"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"issue":"8","key":"e_1_2_1_11_2","first-page":"1","article-title":"Cancer in Canada 1985, 1986","volume":"3","author":"Statistics Canada","year":"1991","journal-title":"Health Rep"},{"key":"e_1_2_1_12_2","volume-title":"Rates and rate standardization, Statistical Methods in Cancer Research: The Design and Analysis of Cohort Studies","author":"Breslow NE","year":"1987"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.1.65"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(80)90007-4"},{"issue":"1","key":"e_1_2_1_15_2","first-page":"S15","article-title":"Lung cancer and scleroderma","volume":"280","author":"Winkelmann RK","year":"1988","journal-title":"Arch Dermatol Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260602"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1001\/archinte.1985.00360100097016","article-title":"The frequency of malignancy in patients with polymyositis and dermatomyositis","volume":"145","author":"Manchul LA","year":"1985","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_18_2","first-page":"24","article-title":"T lymphocyte subset abnormalities and HLA antigens in systemic sclerosis","volume":"76","author":"Barnett AJ","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199002060-00009"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1973.00320100078010"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780360405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780360405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:08:32Z","timestamp":1700716112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780360405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1002\/art.1780360405"],"URL":"https:\/\/doi.org\/10.1002\/art.1780360405","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}