{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:32:35Z","timestamp":1774438355061,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To examine the distribution of HLA class II alleles in clinically distinct juvenile rheumatoid arthritis (JRA) subsets.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> We typed 298 patients and 181 controls for <jats:italic>HLA\u2013DRB1, DQA1, DQB1<\/jats:italic>, and <jats:italic>DPB1<\/jats:italic> alleles using polymerase chain reaction and oligonucleotide probe techniques.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Each JRA subset was characterized by a distinct distribution of HLA class II alleles. For the persistently pauciarticular and rheumatoid factornegative polyarticular JRA subsets, certain combinations of <jats:italic>DRB1<\/jats:italic> and <jats:italic>DPB1<\/jats:italic> alleles were characteristic. In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of <jats:italic>DRB1*0101\/02<\/jats:italic> and <jats:italic>DQA1*0101.<\/jats:italic><\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Findings of HLA typing support clinical subdivisions of the disease and suggest the existence of a novel <jats:italic>DRB1*0101\/02<\/jats:italic> and <jats:italic>DQA1*0101<\/jats:italic> associated disease subset.<\/jats:p>","DOI":"10.1002\/art.1780360406","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:40:09Z","timestamp":1171500009000},"page":"465-472","source":"Crossref","is-referenced-by-count":58,"title":["Hla class ii alleles and heterogeneity of juvenile rheumatoid arthritis. <i>drb1*0101<\/i> may define a novel subset of the disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Rafal","family":"Ploski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odd","family":"Vinje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjersti","family":"S. R\u00f8nningen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Spurkland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag","family":"S\u00f8rskaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frode","family":"Vartdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00f8ystein","family":"F\u00f8rre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109265"},{"key":"e_1_2_1_3_2","first-page":"448","article-title":"HLA\u2010DR antigens in juvenile chronic arthritis","volume":"9","author":"Balogh Z","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260106"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748509165506"},{"key":"e_1_2_1_6_2","first-page":"261","article-title":"HLA antigen frequencies among patients with pauci\u2010articular juvenile chronic arthritis and amyloidosis: a brief report","volume":"4","author":"Burman SJ","year":"1986","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1983.tb01204.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.4.431"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111413"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280207"},{"key":"e_1_2_1_11_2","first-page":"114","article-title":"HLA\u2010DR and MT associations with the clinical and serologic manifestations of pauciarticular onset juvenile rheumatoid arthritis","volume":"12","author":"Sher MR","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290901"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1986.tb00490.x"},{"key":"e_1_2_1_15_2","first-page":"55","article-title":"HLA and complement C4 antigens in polyarticular onset seronegative juvenile rheumatoid arthritis","volume":"16","author":"Hall JH","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9489"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321129"},{"key":"e_1_2_1_18_2","first-page":"1787","article-title":"HLA antigens in juvenile rheumatoid arthritis: pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct","volume":"33","author":"Fink CW","year":"1990","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00211652"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00211643"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1991.tb02030.x"},{"key":"e_1_2_1_22_2","first-page":"874","article-title":"HLA\u2010DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile arthritis","volume":"18","author":"Van Kerckhove C","year":"1991","journal-title":"J Rheumatol"},{"issue":"9","key":"e_1_2_1_23_2","first-page":"S36","article-title":"HLA\u2010DRB1*1104 in chronic iridocyclitis of earlyonset pauciarticular juvenile rheumatoid arthritis (abstract)","volume":"34","author":"Melin\u2010Aldana H","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"2","key":"e_1_2_1_24_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(90)90041-M"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2448875"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(89)90040-2"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01951.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00211994"},{"key":"e_1_2_1_30_2","first-page":"309","article-title":"On estimating the relation between blood group and disease","volume":"20","author":"Woolf B","year":"1956","journal-title":"Ann Hum Genet"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1981.tb01404.x"},{"key":"e_1_2_1_32_2","volume-title":"Genetic variation in HLA system between Ainus, Japanese, and Caucasians, Histocompatibility Testing 1972","author":"Mittal KK","year":"1973"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115814"}],"container-title":["Arthritis &amp; 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