{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:01:15Z","timestamp":1788904875248,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1993,4]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To define the role of HLA\u2013DR pheno\u2010type in the expression of primary Sj\u00f6gren's syndrome (SS).<\/jats:p>Methods.<\/jats:italic> A family study of Caucasian probands with definite primary SS was conducted. Relatives with features of primary SS were classified according to the Fox criteria. Several types of linkage analysis between primary SS and HLA haplotype (HLA\u2013A, B, and DR) were performed.<\/jats:p>Results.<\/jats:italic> A trend toward haplotype sharing between affected siblings was evident for definite\/probable primary SS when analyzed by the Green and Woodrow method. This reached statistical significance when data from other published family studies were included. LOD scores and analyses using the Penrose method showed little evidence of linkage.<\/jats:p>Conclusion.<\/jats:italic> In view of the strong association with HLA\u2010DR3, these results suggest that the HLA\u2010DR3 allele is an important susceptibility factor for expression of primary SS in Caucasians. The apparent haplotype sharing may be a consequence of this association. The potential influence of other genetic factors (major histocompatibility complex [MHC] and non\u2010MHC) is discussed.<\/jats:p>","DOI":"10.1002\/art.1780360407","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:40:09Z","timestamp":1171500009000},"page":"473-484","source":"Crossref","is-referenced-by-count":18,"title":["Linkage studies of hla and primary sj\u00f6gren's syndrome in multicase families"],"prefix":"10.1002","volume":"36","author":[{"given":"Helen Foster,","family":"Mrcp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-6-748"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.5.533"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90820-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210308"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704212961602"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748109095284"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.5.309"},{"key":"e_1_2_1_10_2","first-page":"584","article-title":"Evidence that autoimmunity in man is a Mendelian dominant trait","volume":"39","author":"Bias WB","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1968.tb00058.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1969.tb01646.x"},{"key":"e_1_2_1_13_2","volume-title":"Genetic linkage, Methodology in Medical Genetics: An Introduction to Statistical Methods","author":"Emery AEH","year":"1986"},{"key":"e_1_2_1_14_2","first-page":"588","article-title":"Estimation of the recombinant fraction in human pedigrees: efficient computation of the likelihood for human linkage studies","volume":"26","author":"Ott J","year":"1974","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/30.6.437"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb01076.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1946.tb02340.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290501"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0307-742X(21)00447-1","article-title":"HLA antigens","volume":"9","author":"Dewar PJ","year":"1983","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_20_2","first-page":"21","article-title":"Molecular genetics of the MHC","volume":"1","author":"Trowsdale J","year":"1988","journal-title":"Immunol Suppl"},{"key":"e_1_2_1_21_2","unstructured":"FosterH KellyC FayA CharlesP WalkerD GriffithsI:Autoantibodies and autoimmune disease in a family study of primary Sj\u00f6gren's syndrome. 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