{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T20:49:16Z","timestamp":1773607756025,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To test synovial fluid (SF) for the presence of soluble fragments originating from distinct tumor necrosis factor receptors (TNF\u2010sR55 and TNF\u2010sR75) which bind to TNF and inhibit its biologic activity.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> TNF\u2010sR55 and TNF\u2010sR75 were measured in 62 SF samples by specific immunoassays using monoclonal antibodies.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Both TNF\u2010sR were present in all of the SF tested. Their concentrations were higher in SF from patients with seropositive rheumatoid arthritis than in patients with other inflammatory arthritides. The relative amount of TNF\u2010sR75, as compared with TNF\u2010sR55, was higher in seropositive RA SF than in other SF.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The balance between TNF and its specific inhibitors may be critical to the biologic outcome mediated by this cytokine.<\/jats:p>","DOI":"10.1002\/art.1780360408","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:40:09Z","timestamp":1171500009000},"page":"485-489","source":"Crossref","is-referenced-by-count":95,"title":["Soluble tumor necrosis factor receptors in human inflammatory synovial fluids"],"prefix":"10.1002","volume":"36","author":[{"given":"Pascale","family":"Roux\u2010Lombard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Punzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Hasler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvette","family":"Bas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Todesco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Gallati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Andr\u00e9","family":"Guerne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Dayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330302"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(89)90154-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340908"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1511"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5188"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0021-9258(19)40049-5","article-title":"Two tumor necrosis factor\u2010binding proteins purified from human urine: evidence for immunological cross\u2010reactivity with cell surface tumor necrosis factor receptors","volume":"265","author":"Engelmann H","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114853"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3127"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.2.599"},{"key":"e_1_2_1_11_2","first-page":"5602","article-title":"Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients","volume":"51","author":"Aderka D","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","first-page":"20","article-title":"Imbalance between tumor necrosis factor and soluble TNF receptor concentrations in severe meningococcaemia","volume":"76","author":"Girardin E","year":"1992","journal-title":"Immunology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90591-C"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-1229(05)80029-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220734"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90116-O"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422933"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.2.323"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780360408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780360408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:08:51Z","timestamp":1700716131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780360408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1002\/art.1780360408"],"URL":"https:\/\/doi.org\/10.1002\/art.1780360408","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}