{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:25:30Z","timestamp":1785173130378,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4605,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To determine the frequency of HLA class II antigens in Caucasian central European patients with relapsing polychondritis (RP).<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> HLA class I, DR, and DQ specificities were identified in 41 patients with RP, and the frequencies were compared with those in 204 healthy, unrelated control subjects. HLA typing was performed using the standard complement\u2010dependent microcytotoxicity assay. HLA\u2013DR genotyping of 12 DR4\u2010positive RP patients and 57 controls was performed by allele\u2010specific oligonucleotide probing after amplification of genomic DNA by polymerase chain reaction.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> A significant increase in DR4 antigen frequency was found in the patients (56.1%) as compared with that in healthy controls (25.5%) (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> &lt; 0.001). Genotyping of DR4\u2010positive patients and controls revealed no predominance of any DR4 subtype.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> There are important clinical similarities and overlaps between RP and rheumatoid arthritis (RA). In RA, the association with DR4 has been well established. Our findings show that although there is a DR4 association with RP, the situation is sufficiently distinct from that of RA to imply considerable differences in pathogenesis of the two conditions.<\/jats:p>","DOI":"10.1002\/art.1780360513","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:40:02Z","timestamp":1171500002000},"page":"660-664","source":"Crossref","is-referenced-by-count":114,"title":["Susceptibility to relapsing polychondritis is associated with hla\u2013\u2010dr4"],"prefix":"10.1002","volume":"36","author":[{"given":"Bernhard","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rothenfusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry S.","family":"Lanchbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Rauh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand C.","family":"Breedveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlette","family":"Urlacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard D.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Hartmut","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Melchers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Polychondritis, Textbook of Rheumatology","author":"Herman JH","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-60-4-653"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-1-74"},{"key":"e_1_2_1_6_2","first-page":"367","article-title":"Classical rheumatoid arthritis associated with nondeforming relapsing polychondritis","volume":"14","author":"Tishler M","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02206849"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.12.1021"},{"key":"e_1_2_1_9_2","first-page":"1263","article-title":"Classical rheumatoid arthritis associated with relapsing polychondritis","volume":"16","author":"Rajaee A","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804202981602"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6148.1326"},{"key":"e_1_2_1_12_2","volume-title":"Rheumatoid arthritis, Histocompatibility Testing 1980","author":"Stastny P","year":"1980"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92614-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10049"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330704"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274843"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(75)90022-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/204998b0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(90)90110-B"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811302992202"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.5.473"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331006"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107215"},{"key":"e_1_2_1_25_2","first-page":"497","article-title":"Cell\u2010mediated immunity to cartilage proteoglycan in relapsing polychondritis","volume":"16","author":"Rajapakse DA","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748409111304"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.2.535"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250304"},{"key":"e_1_2_1_29_2","first-page":"180","article-title":"Genetic control of type II collagen\u2010induced arthritis in mice: factors influencing disease susceptibility and evidence for multiple MHC\u2010associated gene control","volume":"15","author":"Wooley PH","year":"1983","journal-title":"Transplant Proc"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830188809044766"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.5.1331"},{"key":"e_1_2_1_32_2","first-page":"373","article-title":"Serum IgG anti\u2010native type II collagen antibodies in rheumatoid arthritis: association with HLA DR4 and lack of clinical correlation","volume":"6","author":"Banerjee S","year":"1988","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270502"},{"key":"e_1_2_1_34_2","first-page":"865","article-title":"Autoimmunity to native type II collagen: a distinct genetic subset of rheumatoid arthritis","volume":"12","author":"Klimiuk PS","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.8.578"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1981.tb00726.x"},{"key":"e_1_2_1_37_2","first-page":"820","article-title":"Relapsing polychondritis: pathogenic role of anti\u2010native collagen type II antibodies","volume":"8","author":"Meyer O","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132907"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.28.232"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340115"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.29.91"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.7.534"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780360513","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780360513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T04:28:12Z","timestamp":1700713692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780360513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1002\/art.1780360513"],"URL":"https:\/\/doi.org\/10.1002\/art.1780360513","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}