{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:23:10Z","timestamp":1791235390752,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4574,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To investigate the involvement of Epstein\u2010Barr virus (EBV) in the pathogenesis of Sj\u00f6gren's syndrome (SS) and to examine whether the spontaneous production of EBV is unique to SS B cell lines.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> B cell lines were established from peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus, rheumatoid arthritis, and SS. The cord blood immortalization assay, flow cytometric analysis, and polymerase chain reaction (PCR) were used to detect EBV production by B cell lines.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> SS B cell lines produced EBV at a higher frequency, and in significantly larger amounts, than did other B cell lines. However, no correlation with the amount of EBV DNA in the genome of B cell lines was found. PCR analysis revealed that EBV with a B95\u20108\u2013like U2 region was dominant in SS B cell lines.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Spontaneous, massive production of EBV by B cell lines is unique to SS, and may contribute to the polyclonal B cell activation seen in this disease.<\/jats:p>","DOI":"10.1002\/art.1780360614","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:39:58Z","timestamp":1171499998000},"page":"827-835","source":"Crossref","is-referenced-by-count":38,"title":["Spontaneous production of epstein\u2010barr virus by b lymphoblastoid cell lines obtained from patients with sj\u00f6gren's syndrome. possible involvement of a novel strain of epstein\u2010barr virus in disease pathogenesis"],"prefix":"10.1002","volume":"36","author":[{"given":"Mutsuto","family":"Tateishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohtaro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92384-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.51.3.795-798.1984"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.4049\/jimmunol.122.4.1310","article-title":"Polyclonal immunoglobulin secretion by 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