{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:06:25Z","timestamp":1784635585841,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4574,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To characterize autoantibodies to chromatin components in patients with juvenile rheumatoid arthritis (JRA).<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> The sera of 50 children with JRA were analyzed for antinuclear antibodies (ANA) by immunofluorescence and enzyme\u2010linked immunosorbent assay (ELISA) techniques.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> By immunofluorescence, ANA and antibodies to high\u2010mobility group proteins or to DNA\u2010free histones were common in patients with pauciarticular JRA and rheumatoid factor\u2013positive polyarticular JRA. However, reactivity with histone\u2013DNA complexes was rare.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Because antihistone antibodies detected by ELISA failed to bind chromatin or other histone\u2013DNA complexes, they are not likely to represent the immunofluorescent ANA activity in serum.<\/jats:p>","DOI":"10.1002\/art.1780360615","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:39:58Z","timestamp":1171499998000},"page":"836-841","source":"Crossref","is-referenced-by-count":24,"title":["Autoantibodies to chromatin components in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"36","author":[{"given":"Rufus W.","family":"Burlingame","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90091-8"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"A review of current concepts on the pathogenesis of juvenile rheumatoid arthritis","volume":"17","author":"Lang BA","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90013-1"},{"key":"e_1_2_1_5_2","volume-title":"The HMG Chromosomal Proteins","author":"Johns EW","year":"1982"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/j.2326-5205.1989.tb00019.x","article-title":"Antibodies to histones H1 and H5 in sera of patients with juvenile rheumatoid arthritis","volume":"32","author":"Pauls JD","year":"1989","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/j.2326-5205.1989.tb00025.x","article-title":"Reactivity of antinuclear antibodies with histones and other antigens in juvenile rheumatoid arthritis","volume":"32","author":"Malleson P","year":"1989","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.2.114"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235131"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331212"},{"key":"e_1_2_1_11_2","first-page":"358","article-title":"Autoantibody profiles in juvenile arthritis","volume":"13","author":"Haynes DC","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_12_2","first-page":"512A","article-title":"Antinuclear antibody specificity in juvenile rheumatoid arthritis (abstract)","volume":"33","author":"Saulsbury FT","year":"1985","journal-title":"Clin Res"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330910"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115353"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00261a026"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00456a018"},{"key":"e_1_2_1_17_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90380-E"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90066-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109161"},{"issue":"4","key":"e_1_2_1_21_2","first-page":"S57","article-title":"Studies on the specificity of antinuclear antibodies in juvenile rheumatoid arthritis (abstract)","volume":"26","author":"Rosenberg AM","year":"1983","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00622.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(82)90166-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350418"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90093-6"}],"container-title":["Arthritis &amp; 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