{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:37Z","timestamp":1761155017695},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4452,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To determine whether <jats:italic>Shigella flexneri<\/jats:italic> strains that cause enteric infection and are associated with reactive arthritis (ReA) carry a 2\u2010Md plasmid, pHS\u20102, which encodes an HLA\u2013B27 mimetic epitope.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Plasmid DNA from <jats:italic>Shigella<\/jats:italic> isolates was characterized by DNA\u2013DNA hybridization, restriction endonuclease digestion, and sequencing.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> S flexneri strains associated with ReA carried a 2\u2010Md plasmid homologous to pHS\u20102.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The finding of pHS\u20102 in additional <jats:italic>Shigella<\/jats:italic> strains associated with ReA underscores its potential importance in the etiology of the disease.<\/jats:p>","DOI":"10.1002\/art.1780361010","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:48:57Z","timestamp":1171500537000},"page":"1387-1391","source":"Crossref","is-referenced-by-count":26,"title":["Association between reactive arthritis and antecedent infection with <i>shigella flexneri<\/i> carrying a 2\u2010md plasmid and encoding an hla\u2013b27 mimetic epitope"],"prefix":"10.1002","volume":"36","author":[{"given":"H.","family":"Stieglitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lipsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"996","article-title":"Reiter's disease and HLA\u2010B27","author":"Brewerton DA","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0889-857X(21)00712-2","article-title":"Ankylosing spondylitis is caused by Klebsiella:evidence from immunologic, microbiologic and serologic studies","volume":"18","author":"Ebringer A","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320802"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.1.364"},{"key":"e_1_2_1_6_2","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Maniatis T","year":"1982"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01947.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(92)90024-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-5-564"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780361010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780361010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:38:26Z","timestamp":1700725106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780361010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1002\/art.1780361010"],"URL":"https:\/\/doi.org\/10.1002\/art.1780361010","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}