{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:53:21Z","timestamp":1764996801258},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4360,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. Endogenous synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis (JRA) was investigated.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Cysteinyl leukotriene synthesis was assessed by measuring the excretion of leukotriene E<jats:sub>4<\/jats:sub> (LTE<jats:sub>4<\/jats:sub>) in urine by radioimmunoassay. The identity of urinary LTE<jats:sub>4<\/jats:sub> was investigated by gas chromatography\u2014mass spectrometry (GC\u2010MS), and 2,3\u2010dinor\u2010thromboxane B<jats:sub>2<\/jats:sub> was measured with GC\u2010MS.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Excretion of LTE<jats:sub>4<\/jats:sub> into urine was significantly (<jats:italic>P<\/jats:italic> &lt; 0.05) enhanced in children with JRA compared with that in healthy children (n = 10). Aspirin, in a dosage of 2.5 gm\/day, had no effect on urinary LTE<jats:sub>4<\/jats:sub> levels, but it reduced urinary 2,3\u2010dinorthromboxane B<jats:sub>2<\/jats:sub> levels by more than 85% in healthy adults. There was a positive correlation between LTE<jats:sub>4<\/jats:sub> excretion and the number of affected joints.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. This study demonstrates a markedly enhanced cysteinyl leukotriene synthesis and a positive correlation between LTE<jats:sub>4<\/jats:sub> excretion and the number of affected joints in children with JRA.<\/jats:p>","DOI":"10.1002\/art.1780370114","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:04:15Z","timestamp":1171501455000},"page":"93-97","source":"Crossref","is-referenced-by-count":26,"title":["Enhanced Synthesis of Cysteinyl Leukotrienes in Juvenile Rheumatoid Arthritis"],"prefix":"10.1002","volume":"37","author":[{"given":"J.","family":"Fauler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Thon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tsikas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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