{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:51:37Z","timestamp":1770702697434,"version":"3.49.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4360,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To define the influence of the T cell receptor (TCR) and the <jats:italic>lpr<\/jats:italic> autoimmune gene on the induction and progression of superantigen\u2010induced arthritis in V <jats:sub>\u03b2<\/jats:sub>8 transgenic MRL\u2010<jats:italic>lpr\/lpr<\/jats:italic> mice.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> The time to onset and the extent of synovial hyperplasia after the induction of arthritis by intraarticular injection of staphylococcal enterotoxin B (SEB) were compared in mice having T cells that bear the V <jats:sub>\u03b2<\/jats:sub>8 transgene alone (V <jats:sub>\u03b2<\/jats:sub>8 TCR transgenic MRL\u2010+\/+), the <jats:italic>lpr<\/jats:italic> gene without the V <jats:sub>\u03b2<\/jats:sub>8 gene (nontransgenic MRL\u2010<jats:italic>lpr\/lpr<\/jats:italic>), both the V <jats:sub>\u03b2<\/jats:sub>8 gene and the <jats:italic>lpr<\/jats:italic> gene (V <jats:sub>\u03b2<\/jats:sub>8 transgenic MRL\u2010<jats:italic>lpr\/lpr<\/jats:italic>), or neither gene (nontransgenic MRL\u2010+\/+). Synovial hyperplasia was compared in SEB\u2010injected V <jats:sub>\u03b2<\/jats:sub>8 transgenic MRL\u2010<jats:italic>lpr\/lpr<\/jats:italic> mice after treatment with cyclosporin A (CSA), anti\u2010V <jats:sub>\u03b2<\/jats:sub>8 and anti\u2010CD4 monoclonal antibodies, and in V <jats:sub>\u03b2<\/jats:sub>8 transgenic MRL\u2010<jats:italic>lpr\/lpr<\/jats:italic> mice after injection of a non\u2014V <jats:sub>\u03b2<\/jats:sub>8\u2010reactive superantigen, staphylococcal enterotoxin A (SEA).<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> At day 30, increased synovial cells were observed in all SEB\u2010treated mice, but the increase was greatest in the V <jats:sub>\u03b2<\/jats:sub>8 transgenic MRL\u2010<jats:italic>lpr\/lpr<\/jats:italic> mice. T cell involvement was indicated by the inability of either heat\u2010denatured SEB or SEA to induce severe arthritis, the reduction in the severity of the arthritis on systemic treatment with CSA or anti\u2010V <jats:sub>\u03b2<\/jats:sub>8, and the correlation of synovial hyperplasia with in vitro SEB reactivity of T cells.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> These observations suggest that super\u2010antigens can induce chronic arthritis and that the induction and progression of the arthritis requires an underlying T cell defect in anergy induction in addition to exposure to the superantigen.<\/jats:p>","DOI":"10.1002\/art.1780370117","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:04:15Z","timestamp":1171501455000},"page":"113-124","source":"Crossref","is-referenced-by-count":12,"title":["T Cell Influence on Superantigen\u2010Induced Arthritis in MRL\u2010<i>lpr\/lpr<\/i> Mice"],"prefix":"10.1002","volume":"37","author":[{"given":"John D.","family":"Mountz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Bluethmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Carl K.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90568-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2511629"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1694041"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/342564a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2125368"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350702"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.10.3247"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340202"},{"key":"e_1_2_1_10_2","first-page":"325","article-title":"Therapeutic use of monoclonal anti\u2010CD4 antibody in rheumatoid arthritis","volume":"18","author":"Wendling D","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340504"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360304"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330902"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4049\/jimmunol.138.1.157","article-title":"CsA therapy in MRL\u2010lpr\/lpr mice: amelioration of immunopathology despite autoantibody production","volume":"138","author":"Mountz JD","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1857971"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340412"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780311213"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210231"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10921"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.891"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330224"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341009"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340505"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330602"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.5.1573"},{"key":"e_1_2_1_26_2","first-page":"1","article-title":"Etiopathogenesis of rheumatoid arthritis\u2010like disease in MRL\/1 mice. 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