{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:10:56Z","timestamp":1788588656530,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4301,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To determine the cost\u2010utility of low\u2010dose misoprostol prophylaxis in rheumatoid arthritis (RA) patients treated with nonsteroidal antiinflammatory drugs (NSAIDs).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Prospectively collected, population\u2010ased data on 57 RA patients' preferences (obtained using the category scaling and time trade\u2010off techniques), charge data from a consecutive, populationbased cohort of 36 RA patients with NSAID\u2010related gastric ulcer, and literature\u2010derived probability estimates were incorporated into a decision analysis model.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Probabilistic sensitivity analysis using 10,000 Monte Carlo simulations demonstrated that, on average, prophylaxis resulted in modest additional costs and no additional quality\u2010of\u2010life benefits. At best, the incremental cost per quality\u2010adjusted life year gained was $9,333. At worst, prophylaxis reduced quality of life. Prophylaxis was cost\u2010saving if the ulcer complication rate was &gt; 1.5%, or if the 3\u2010month price of misoprostol was \u2264$95.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Whereas prophylaxis may be costsaving among high\u2010risk NSAID users, from some patients' perspective, it reduces quality of life. Although these data may not be generalizable to other clinical populations, they illustrate the importance of incorporating patient preferences into economic evaluations.<\/jats:p>","DOI":"10.1002\/art.1780370306","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:15:56Z","timestamp":1171502156000},"page":"333-341","source":"Crossref","is-referenced-by-count":33,"title":["A Cost\u2010Utility Analysis of Misoprostol Prophylaxis for Rheumatoid Arthritis Patients Receiving Nonsteroidal Antiinflammatory Drugs"],"prefix":"10.1002","volume":"37","author":[{"given":"Sherine E.","family":"Gabriel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Campion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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