{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:22:22Z","timestamp":1761128542669},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To examine the relationship of rheumatoid factor (RF) to HLA\u2013DR4 and alleles of DRB1 in women with recent\u2010onset rheumatoid arthritis (RA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Incident cases of RA were identified as part of a prospective, population\u2010based case\u2013control study. HLA typing was completed for 246 cases meeting criteria for definite or classic RA.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. One hundred thirty\u2010six patients (55%) were positive for DR4, and 130 (53%) were RF positive. DR4 was found to be strongly associated with seropositivity (odds ratio 4.1, <jats:italic>P<\/jats:italic> &lt; 0.0001). Patients with a shorter interval from RA onset to RF testing had a higher frequency of seropositivity than those with a longer interval (\u226418 months 60%, &gt;18 months 33%). Further analysis of patients who had RF testing within 18 months of RA onset showed that the frequency of seropositivity was significantly greater among DR4\u2010positive patients who had the shared sequence stretch of DR\u03b21 associated with RA susceptibility (76% RF positive) than among DR1\u2010positive patients who had this sequence (45% RF positive) (odds ratio 3.8, <jats:italic>P<\/jats:italic> = 0.01). Moreover, the frequency of seropositivity among DR1\u2010positive patients with the sequence did not differ from that among all patients without the shared sequence (47%) (odds ratio 0.9, <jats:italic>P<\/jats:italic> = 0.8).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. HLA\u2013DR4 is strongly associated with seropositivity in women with recent\u2010onset RA. The amino acid sequence of DR\u03b21 that is associated with susceptibility to RA and is shared between DR4 and DR1 appears not to be the primary determinant of seropositivity in these women.<\/jats:p>","DOI":"10.1002\/art.1780370510","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:15:04Z","timestamp":1171502104000},"page":"673-680","source":"Crossref","is-referenced-by-count":27,"title":["Rheumatoid factor, HLA\u2013DR4, and allelic variants of DRB1 in women with recent\u2010onset rheumatoid arthritis"],"prefix":"10.1002","volume":"37","author":[{"given":"J.","family":"Lee Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carin E.","family":"Dugowson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Koepsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda F.","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Branchaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Barrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Wener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"307","article-title":"Autoimmune disease and HLA","volume":"10","author":"Nelson JL","year":"1990","journal-title":"Crit Rev Immunol"},{"key":"e_1_2_1_2_3","first-page":"454","volume":"10","year":"1990","journal-title":"Crit Rev Immunol"},{"key":"e_1_2_1_3_2","first-page":"1863","article-title":"HLA\u2010Dw4 in adult and juvenile rheumatoid arthritis","volume":"9","author":"Stastny P","year":"1977","journal-title":"Transplant Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-8545-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330704"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321006"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01932.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0889-857X(21)00150-2","article-title":"The genetic basis of rheumatoid arthritis: the shared epitope hypothesis","volume":"18","author":"Winchester R","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_9_2","first-page":"18","article-title":"Pregnancy outcome in women with rheumatoid arthritis before disease onset","volume":"19","author":"Nelson JL","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_11_2","first-page":"888","article-title":"The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis","volume":"21","author":"Singer JM","year":"1956","journal-title":"Am J Med"},{"key":"e_1_2_1_12_2","volume-title":"NIAID Manual of Tissue Typing Techniques, 1979\u20131980","author":"Ray JG","year":"1979"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230505"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1991.tb01891.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01984.x"},{"key":"e_1_2_1_16_2","volume-title":"BMDP Statistical Software Manual","author":"Dixon WJ","year":"1990"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5858.96"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1991.tb01888.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320129"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280503"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.8.627"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.5.406"},{"key":"e_1_2_1_23_2","unstructured":"KoepsellTD DugowsonCE NelsonJL VoigtLF DalingJR:Oral contraceptive use and the incidence of rheumatoid arthritis in women. Submitted for publication"},{"issue":"9","key":"e_1_2_1_24_2","first-page":"S48","article-title":"Is nulliparity a risk factor for rheumatoid arthritis (abstract)","volume":"34","author":"Dugowson CE","year":"1991","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350306"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02421540"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3458307"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/j.2326-5205.1989.tb00013.x","article-title":"A model for disease heterogeneity in systemic lupus erythematosus: relationships between histocompatibility antigens, autoantibodies, and lymphopenia or renal disease","volume":"32","author":"Harley JB","year":"1989","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/327426a0"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115814"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.1.23"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(88)90013-3"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.8.519"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340707"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270104"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780370510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780370510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:56:22Z","timestamp":1700765782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780370510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["10.1002\/art.1780370510"],"URL":"https:\/\/doi.org\/10.1002\/art.1780370510","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}