{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T16:38:27Z","timestamp":1720629507232},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1994,5]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To evaluate and extend upon a reported association of a T cell receptor (TCR) V \u03b2<\/jats:sub> coding region polymorphism with pauciarticular\u2010onset juvenile rheumatoid arthritis (JRA).<\/jats:p>Methods<\/jats:italic>. TCR V \u03b2<\/jats:sub>6.1 genotypes and haplotypes in JRA and control groups were determined by DNA amplification.<\/jats:p>Results<\/jats:italic>. Haplotypes of the V \u03b2<\/jats:sub>6.1 gene which encode a nonfunctional form of V \u03b2<\/jats:sub>6.1 were significantly associated with pauciarticular JRA in patients possessing the HLA\u2013DQA1*0101 allele (P<\/jats:italic> = 0.0073).<\/jats:p>Conclusion<\/jats:italic>. A TCR V \u03b2<\/jats:sub> gene segment in the vicinity of V \u03b2<\/jats:sub>6.1, possibly V \u03b2<\/jats:sub>6.1, is apparently involved in the pathogenesis of pauciarticular\u2010onset JRA in DQA1*0101\u2010positive individuals.<\/jats:p>","DOI":"10.1002\/art.1780370513","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:15:04Z","timestamp":1171502104000},"page":"695-701","source":"Crossref","is-referenced-by-count":22,"title":["HLA and T cell receptor \u03b2\u2010chain DNA polymorphisms identify a distinct subset of patients with pauciarticular\u2010onset juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"37","author":[{"given":"Patrick","family":"Charmley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara 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