{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:02:15Z","timestamp":1791028935906,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To determine the content of two crosslinks, pyridinoline (a mature crosslink) and pentosidine (a senescent crosslink), in human articular cartilage, and to examine the effect of bone and joint disorders on the content of those crosslinks in articular cartilage.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. After pretreatment with SP\u2010Sephadex C\u201025, high\u2010performance liquid chromatography was conducted on a hydrolysate of human articular cartilage from 53 patients with one of the following diseases: osteoarthritis (OA), rheumatoid arthritis (RA), osteoporosis, femoral head necrosis, and renal osteodystrophy (ROD).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Pyridinoline levels were either unchanged with age or were slightly decreased in elderly patients. Pentosidine levels increased with age in the entire patient population. There was no significant difference in the pyridinoline content among the study groups, but there was a significant difference in pentosidine content (<jats:italic>P<\/jats:italic> &lt; 0.001). ROD patients had the highest mean level of pentosidine (407 \u03bcmoles\/mole of hydroxyproline), and RA patients had a higher mean level than age\u2010matched OA patients (214 versus 103 \u03bcmoles\/mole of hydroxyproline).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Bone and joint disorders do not affect the pyridinoline content in articular cartilage, but they do affect the pentosidine content.<\/jats:p>","DOI":"10.1002\/art.1780370517","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:15:04Z","timestamp":1171502104000},"page":"724-728","source":"Crossref","is-referenced-by-count":55,"title":["Quantitative analysis of crosslinks pyridinoline and pentosidine in articular cartilage of patients with bone and joint disorders"],"prefix":"10.1002","volume":"37","author":[{"given":"Masaaki","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Kushida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Kawana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)90972-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a131983"},{"key":"e_1_2_1_4_2","first-page":"49","article-title":"The cartilage collagens: structural and metabolic studies","volume":"18","author":"Eyre DR","year":"1991","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(82)80132-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92363-K"},{"key":"e_1_2_1_7_2","first-page":"964","article-title":"Urinary hydroxy\u2010pyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases","volume":"16","author":"Seibel MJ","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.11.759"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"21597","DOI":"10.1016\/S0021-9258(20)88225-8","article-title":"Structure elucidation of a senescence cross\u2010link from human extracellular matrix","volume":"264","author":"Sell DR","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114449"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.2.153"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1093\/clinchem\/39.10.2162","article-title":"Quantitation of the cross\u2010link, pentosidine in serum from normal and uremic subjects","volume":"39","author":"Takahashi M","year":"1993","journal-title":"Clin Chem"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404078"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a123646"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079308020958"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.2.S36"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2520495"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.10.864"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"11654","DOI":"10.1016\/S0021-9258(18)99007-1","article-title":"Formation of pentosidine during nonenzymatic browning of proteins by glucose","volume":"266","author":"Dyer DG","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.2.S42"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780370517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780370517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:57:04Z","timestamp":1700765824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780370517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["10.1002\/art.1780370517"],"URL":"https:\/\/doi.org\/10.1002\/art.1780370517","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}