{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:21:19Z","timestamp":1787620879184,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4209,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective. To test treatment regimens for Lyme arthritis.\nMethods. Patients were randomly assigned to treatment with doxycycline or amoxicillin plus probenecid for 30 days. Patients who had persistent arthritis for at least 3 months after treatment with oral antibiotics or parenteral penicillin were given intravenous ceftriaxone for 2 weeks.\nResults. Eighteen of the 20 patients treated with doxycycline and 16 of the 18 patients who completed the amoxicillin regimen had resolution of the arthritis within 1\u20133 months after study entry. However, neuroborreliosis later developed in 5 patients, 4 of whom had received the amoxicillin regimen. Of 16 patients (2 from the oral antibiotic study and 14 additional patients) who had persistent arthritis despite previous oral antibiotics or parenteral penicillin, none had resolution of the arthritis within 3 months after ceftriaxone therapy. The HLA\u2010DR4 specificity and OspA reactivity were associated with a lack of response.\nConclusion. Lyme arthritis can usually be treated successfully with oral antibiotics, but patients may still develop neuroborreliosis. Patients with certain genetic and immune markers may have persistent arthritis despite treatment with oral or intravenous antibiotics.<\/jats:p>","DOI":"10.1002\/art.1780370616","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:12:54Z","timestamp":1171501974000},"page":"878-888","source":"Crossref","is-referenced-by-count":217,"title":["Treatment of lyme arthritis"],"prefix":"10.1002","volume":"37","author":[{"given":"Allen C.","family":"Steere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kalish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H. ,","family":"Abraham Iii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210906"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-1-76"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-725"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-6-896"},{"key":"e_1_2_1_6_2","first-page":"26","article-title":"Lyme arthritis: spirochetes found in synovial microangiopathic lesions","volume":"118","author":"Johnston YE","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310405"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121401"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80688-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92011-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230402"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(91)90044-A"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.7.2774-2779.1993"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.Supplement_6.S1505"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013102"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93103-V"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90270-L"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-6-472"},{"key":"e_1_2_1_19_2","first-page":"95","article-title":"Treatment of Lyme disease","volume":"34","year":"1992","journal-title":"Med Lett"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.2.392"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_1_22_2","volume-title":"Applied Logistic Regression","author":"Hosmer DW","year":"1989"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-4-281"},{"key":"e_1_2_1_24_2","first-page":"74","article-title":"The use of doxycycline in nervous system Borrelia burgdorferi infection","volume":"53","author":"Dotevall L","year":"1988","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.7.1078"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.2.303"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.11.1700"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011223232102"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.753"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401273300401"},{"issue":"9","key":"e_1_2_1_31_2","first-page":"S41","article-title":"The humoral immune response to the OspA protein of Borrelia burgdorferi in Lyme disease (abstract)","volume":"36","author":"Kalish RA","year":"1993","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211016"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90006-3"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241217"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340817"}],"container-title":["Arthritis &amp; 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