{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:12:58Z","timestamp":1769278378941,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4209,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective. Clinical trials have suggested that the efficacy of bucillamine (BUC) in rheumatoid arthritis (RA) may be superior to that of D\u2010penicillamine (DP), although the basis of the differences remains unclear. Previous studies have revealed that BUC has unique immunomodulatory effects that depend upon its capacity to form an intramolecular disulfide (BUG\u2010ID). We therefore examined the effects of BUC\u2010ID on the in vitro function of human B cells and T cells compared with those of DP, at their pharmacologically attainable concentrations.\nMethods. IgM production was induced in highly purified B cells from healthy donors by stimulation with Staphylococcus aureus Cowan 1 (SAC) plus interleukin\u20102 (IL\u20102) or with immobilized anti\u2010CD3\u2013activated CD4+ T cells. Interferon\u2010\u03b3 (IFN\u03b3) production was induced in CD4+ T cells by stimulation with immobilized anti\u2010CD3.\nResults. BUC\u2010ID suppressed IgM production iduced by SAC + IL\u20102 as well as that induced by immobilized anti\u2010CD3\u2013activated CD4+ T cells, whereas DP suppressed the latter more markedly than the former. DP (3 \u03bcg\/ml) significantly suppressed IFN\u03b3 production by immobilized anti\u2010CD3\u2013stimulated CD4+ T cells, but not IgM production induced by SAC + IL\u20102 stimulation. By contrast, BUC\u2010ID (0.3 \u03bcg\/ml) significantly suppressed IgM production induced by SAC + IL\u20102, but not T cell IFN\u03b3 production. Of note, BUC\u2010ID did not suppress IL\u20106 production by SAC\u2010activated B cells.\nConclusion. These results indicate that the target cells of BUC and DP in vivo might be different, with the former inhibiting the function of B cells and the latter that of T cells. The data suggest the possibility that BUC may have a different effect in RA patients compared with the effect of DP, and may be effective in patients who do not respond to DP.<\/jats:p>","DOI":"10.1002\/art.1780370625","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:12:54Z","timestamp":1171501974000},"page":"942-950","source":"Crossref","is-referenced-by-count":30,"title":["Comparative inhibitory effects of bucillamine and d\u2010penicillamine on the function of human b cells and t cells"],"prefix":"10.1002","volume":"37","author":[{"given":"Shunsei","family":"Hirohata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E.","family":"Lipsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"333","article-title":"Clinical evaluation of SA96 on rheumatoid arthritis (in Japanese)","volume":"5","author":"Shiokawa Y","year":"1985","journal-title":"Jpn J Inflamm"},{"key":"e_1_2_1_3_2","first-page":"7","article-title":"Clinical evaluation of immunomodulators","volume":"1","author":"Abe C","year":"1985","journal-title":"Int J Immunother"},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"Bucillamine: a new immunomodulator","volume":"3","author":"Kashiwazaki S","year":"1987","journal-title":"Int J Immunother"},{"key":"e_1_2_1_5_2","first-page":"691","article-title":"Effect of bucillamine (SA96) on type II collagen induced arthritis in rats","volume":"18","author":"Hayashi M","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965074"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240408"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1993.1006"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60299-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1248\/yakushi1947.105.7_665","article-title":"Study on metabolism of dithiol compound. 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