{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:14Z","timestamp":1791400574010,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4179,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. The arthritogenic potential of the cationic outer surface proteins (Osp) from <jats:italic>Borrelia burgdorferi<\/jats:italic> was tested in rats.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Water\u2010soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. The Osps of <jats:italic>Borrelia burgdorferi<\/jats:italic> are potent arthritogens in rats. These immunodominant antigens may play a role in the development of Lyme arthritis in humans.<\/jats:p>","DOI":"10.1002\/art.1780370713","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:12:02Z","timestamp":1171501922000},"page":"1070-1077","source":"Crossref","is-referenced-by-count":27,"title":["Induction of experimental allergic arthritis with outer surface proteins of <i>borrelia burgdorferi<\/i>"],"prefix":"10.1002","volume":"37","author":[{"given":"Klaus B.","family":"Gondolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mihatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Curschellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Batsford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-725"},{"key":"e_1_2_1_3_2","first-page":"26","article-title":"Lyme arthritis: spirochetes found in synovial microangiopathic lesions","volume":"118","author":"Johnston YE","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-6-798"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/jcm.25.7.1148-1150.1987","article-title":"Isolation of Borrelia spirochetes from patients in Texas","volume":"25","author":"Rawlings JA","year":"1987","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.4.905"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.4.842"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.1.133"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/iai.56.9.2336-2342.1988","article-title":"Induction of Lyme arthritis in LSH hamsters","volume":"56","author":"Schmitz JL","year":"1988","journal-title":"Infect Immun"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.4.1427"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111604"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899567"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115348"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1991.tb05110.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.41.2.795-804.1983"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4049\/jimmunol.140.1.265","article-title":"A murine IgM mono\u2010clonal antibody binds an antigenic determinant in outer surface protein A, an immunodominant basic protein of the Lyme disease spirochete","volume":"140","author":"Benach JL","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112683"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(90)85056-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/1046-5928(90)90011-M"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.56"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350220"},{"issue":"1","key":"e_1_2_1_22_2","first-page":"25","article-title":"Do bacterial antigens persist in reactive arthritis","volume":"5","author":"Toivanen A","year":"1987","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310801"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2106\/00004623-198264030-00009","article-title":"The negative charge of articular cartilage surfaces: an electron microscopic study using cationized ferritin","volume":"64","author":"Stanescu R","year":"1982","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_25_2","volume-title":"Biochemistry and metabolism of the normal synovial lining, The Synovial Lining in Health and Disease","author":"Henderson B","year":"1987"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.4.756"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1302"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.5.2182-2191.1993"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4049\/jimmunol.148.1.218","article-title":"Epitopes on the outer surface protein A of Borrelia burgdorferi recognized by antibodies and T cells of patients with Lyme disease","volume":"148","author":"Shanafelt MC","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.4049\/jimmunol.147.6.1968","article-title":"Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin\/tumor necrosis factor synthesis: analysis using a CAT reporter construct","volume":"147","author":"Radolf JD","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1128\/iai.60.2.455-464.1992","article-title":"Demonstration of a B\u2010lymphocyte mitogen produced by the Lyme disease pathogen, Borrelia burgdorferi","volume":"60","author":"Schoenfeld R","year":"1992","journal-title":"Infect Immun"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1128\/iai.60.3.838-844.1992","article-title":"Interactions between extracellular Borrelia burgdorferi proteins and non\u2010Borrelia\u2010directed immunoglobulin M antibodies","volume":"60","author":"Dorward DW","year":"1992","journal-title":"Infect Immun"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(91)90074-K"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.2.671-678.1991"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31845.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/iai.59.6.1916-1921.1991","article-title":"Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters","volume":"59","author":"Schmitz JL","year":"1991","journal-title":"Infect Immun"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.4049\/jimmunol.149.11.3648","article-title":"The hamster immune response to tick\u2010transmitted Borrelia burgdorferi differs from the response to needle\u2010inoculated, cultured organisms","volume":"149","author":"R\u00f6hrig JT","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.4.971"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.7.2774-2779.1993"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780370713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780370713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:23:49Z","timestamp":1700767429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780370713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/art.1780370713"],"URL":"https:\/\/doi.org\/10.1002\/art.1780370713","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}