{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:09:36Z","timestamp":1761109776983},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4179,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of an acute anaphylactic reaction to intravenous cyclophosphamide in a patient with systemic lupus erythematosus. Skin testing for reactivity to cyclophosphamide and one of its metabolites, 4\u2010hydroperoxycyclophosphamide, was performed on the patient and on 6 controls. The patient exhibited positive skin test responses; all controls had negative responses. The results suggest an acute hypersensitivity reaction related to sensitivity to cyclophosphamide and to 4\u2010hydroperoxycyclophosphamide, through a shared antigenic determinant or dual sensitization.<\/jats:p>","DOI":"10.1002\/art.1780370717","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:12:02Z","timestamp":1171501922000},"page":"1101-1104","source":"Crossref","is-referenced-by-count":14,"title":["Immediate hypersensitivity reaction to cyclophosphamide"],"prefix":"10.1002","volume":"37","author":[{"given":"David J.","family":"Knysak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Mclean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Joseph Mccune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-1-66"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(76)90151-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.237.5.475"},{"key":"e_1_2_1_5_2","first-page":"495","article-title":"Allergic reaction to cyclophosphamide in a mechlorethamine\u2010sensitive patient","volume":"61","author":"Ross WE","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_6_2","first-page":"180","article-title":"Acute cyclophosphamide hypersensitivity reaction: possible lack of cross\u2010sensitivity to mechlorethamine and isophosphamide","volume":"62","author":"Legha SS","year":"1978","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_7_2","first-page":"1725","article-title":"Cyclophosphamideinduced urticaria","volume":"138","author":"Krutchek AN","year":"1978","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80178-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90780-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90256-N"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806023182203"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00385a029"},{"key":"e_1_2_1_13_2","volume-title":"Skin testing and other diagnostic procedures, A Manual of Clinical Allergy","author":"Vanselow NA","year":"1967"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162603"},{"key":"e_1_2_1_15_2","first-page":"226","article-title":"Clinical pharmacology of cyclophosphamide","volume":"33","author":"Bagley CM","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.4.821"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780370717","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780370717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:24:15Z","timestamp":1700767455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780370717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/art.1780370717"],"URL":"https:\/\/doi.org\/10.1002\/art.1780370717","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}