{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:43:49Z","timestamp":1782513829254,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4026,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate temporal trends in the incidence of rheumatoid arthritis (RA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Incident cases of RA were identified among a population\u2010based cohort of Pima Indians in Arizona over the period 1965\u20131990.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Among 2,894 subjects, 78 incident cases of RA were identified. The age\u2010adjusted incidence declined by 55% in men (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.225), and by 57% in women (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.017) after controlling for oral contraceptive or estrogen use and for pregnancy experience. During the same period, age\u2010adjusted prevalence rates of active RA decreased by 29% in men (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.63) and by 40% in women (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.02). Fewer than 17% of subjects with known RA were taking slow\u2010acting antirheumatic drugs (SAARDs) in 1990.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. The decrease in incidence and prevalence of RA in this population over such a short period implicates the involvement of an environmental factor(s), other than exogenous estrogens, in the pathogenesis of the disease. However, the possibility that the observed decrease might be explained by an increased use of SAARDs in subjects with RA cannot be excluded.<\/jats:p>","DOI":"10.1002\/art.1780370808","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:11:58Z","timestamp":1171501918000},"page":"1158-1165","source":"Crossref","is-referenced-by-count":85,"title":["Decreasing incidence and prevalence of rheumatoid arthritis in pima indians over a twenty\u2010five\u2014year period"],"prefix":"10.1002","volume":"37","author":[{"given":"Lennart T. 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