{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:06:42Z","timestamp":1770721602040,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4026,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>, To assess the value of measuring serum levels of soluble intercellular adhesion molecule 1 (sICAM\u20101), soluble vascular cell adhesion molecule 1 (sVCAM\u20101), and soluble E\u2010selectin for monitoring disease activity in Wegener's granulomatosis (WG).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. A sandwich enzyme\u2010linked immunosorbent assay was used to measure levels of soluble adhesion molecules at the time of diagnosis in 22 consecutive patients with WG, in 12 WG patients studied serially prior to disease relapse, at the time of upper airways infection in 18 patients with inactive WG, and in 57 controls. Disease activity was assessed by disease activity score and C\u2010reactive protein levels.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. At diagnosis of WG, sICAM\u20101 and sVCAM\u20101 levels were significantly elevated and correlated with disease activity. At the time of relapse, a significant increase in all 3 soluble adhesion molecules was found compared with levels at 6 months prior to relapse, but only sVCAM\u20101 levels were significantly elevated compared with those in controls. Levels of soluble adhesion molecules at the time of relapse did not differ from those measured during an upper airways infection without disease activity.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Elevated serum levels of sICAM\u20101 and sVCAM\u20101 can be found in active WG and correlate with disease activity. However, their clinical relevance for followup is limited due to lack of sensitivity and specificity for WG disease activity.<\/jats:p>","DOI":"10.1002\/art.1780370818","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:11:58Z","timestamp":1171501918000},"page":"1228-1235","source":"Crossref","is-referenced-by-count":56,"title":["Serum levels of soluble adhesion molecules intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E\u2010selectin in patients with wegener's granulomatosis. Relationship to disease activity and relevance during followup"],"prefix":"10.1002","volume":"37","author":[{"given":"Coen A.","family":"Stegeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem Cohen","family":"Tervaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minke G.","family":"Huitema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E. De","family":"Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cees G. 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