{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:08:00Z","timestamp":1761894480917},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":4841,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1994,8]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To assess whether the HLA\u2014DR4 association found in rheumatoid arthritis (RA) is also seen in the large granular lymphocyte (LGL) syndrome.<\/jats:p>Methods<\/jats:italic>. HLA\u2014DR genotyping was performed using restriction fragment length polymorphism and polymerase chain reaction analysis.<\/jats:p>Results<\/jats:italic>. LGL syndrome patients with RA showed the same HLA\u2013DR4 association seen in RA\/Felty's syndrome (FS), while LGL syndrome patients without arthritis did not.<\/jats:p>Conclusion<\/jats:italic>. It is proposed that FS and the LGL syndrome represent different variants of a broader syndrome comprising RA, neutropenia, LGL expansions, HLA\u2014DR4 positivity, and splenomegaly.<\/jats:p>","DOI":"10.1002\/art.1780370909","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:11:19Z","timestamp":1171501879000},"page":"1326-1330","source":"Crossref","is-referenced-by-count":49,"title":["The large granular lymphocyte syndrome with rheumatoid arthritis. immunogenetic evidence for a broader definition of felty's syndrome"],"prefix":"10.1002","volume":"37","author":[{"given":"S. J.","family":"Bowman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sivakumaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Snowdendegs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bhavnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Panayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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