{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:59:21Z","timestamp":1770433161510,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4026,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To determine whether the lack of acute\u2010phase protein (APP) response in numerous patients with polymyositis\/dermatomyositis (PM\/DM) is related to an imbalance between cytokines and cytokine inhibitors.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Levels of C\u2010reactive protein (CRP), interleukin\u20101\u03b2 (IL\u20101\u03b2), tumor necrosis factor \u03b1 (TNF\u03b1), IL\u20106, IL\u20101 receptor antagonist (IL\u20101ra), TNF soluble receptor 55 kd (sTNFR 55 kd), and sTNFR 75 kd were tested in the serum of 15 patients with PM\/DM, 14 patients with spondylarthropathies (SPA), and 12 healthy blood donors. Serum IL\u20101\u03b2, TNF\u03b1, IL\u20106, IL\u20101ra, sTNFR were measured by specific immunoassays.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Serum levels of CRP were lower in PM\/DM patients than in SPA patients. Normal or slightly elevated CRP values were found in 10 of the 15 PM\/DM patients, 7 of whom had active myositis. Serum IL\u20106 levels were significantly higher in SPA patients than in PM\/DM patients, whereas serum IL\u20101ra and sTNFR levels were significantly higher in PM\/DM than in SPA patients. IL\u20101ra levels were particularly elevated in patients with active myositis and decreased in response to treatment.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. These differences in cytokine levels, particularly IL\u20101ra, between PM\/DM and SPA patients are indicative of distinct pathogenic mechanisms. High levels of IL\u20101ra may account for the weak APP response in some PM\/DM patients. Our results suggest that measurement of IL\u20101ra, together with clinical examination, may provide useful information for the followup of PM\/DM patients.<\/jats:p>","DOI":"10.1002\/art.1780371206","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:56:34Z","timestamp":1171500994000},"page":"1744-1751","source":"Crossref","is-referenced-by-count":76,"title":["ELEVATED SERUM LEVELS OF INTERLEUKIN\u20101 RECEPTOR ANTAGONIST IN POLYMYOSITIS\/DERMATOMYOSITIS. A Biologic Marker of Disease Activity with a Possible Role in the Lack of Acute\u2010Phase Protein 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