{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:01:06Z","timestamp":1790355666146,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3875,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To investigate a possible association between human T cell leukemia\/lymphoma virus type I (HTLV\u2010I) and polymyositis (PM).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Sera and muscle biopsy samples from 9 Jamaican PM patients were compared with specimens from American HTLV\u2010I\u2013positive PM patients and normal controls. Sera were evaluated for HTLV antibodies by enzyme\u2010linked immunosorbent assay and Western blot. The biopsy samples were analyzed for HTLV\u2010I\/II DNA by polymerase chain reaction and were also immunohistochemically stained for HTLV gp46 envelope protein.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Seven of the 8 Jamaican PM patients from whom sera were available were HTLV\u2010I seropositive. The muscle biopsies of all 9 Jamaican patients demonstrated severe lymphocytic infiltration, cellular degeneration, myofiber atrophy, and fibrosis. Each muscle biopsy specimen contained HTLV\u2010I DNA. Two of 6 samples demonstrated intense staining for HTLV\u2010I gp46 in many of the invading mononuclear cells and weak staining for HTLV\u2010I gp46 in many of the invading mononuclear cells and weak staining in the adjacent myocytes. Two other specimens were weakly positive for gp46 in rare mononuclear cells. All control specimens were negative for the presence of HTLV\u2010I DNA and protein.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. HTLV\u2010I is associated with an inflammatory muscle disease characterized by direct invasion of the affected muscle by HTLV\u2010I\u2013infected mononuclear cells.<\/jats:p>","DOI":"10.1002\/art.1780380518","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:39:56Z","timestamp":1171503596000},"page":"690-698","source":"Crossref","is-referenced-by-count":29,"title":["Identification of human t cell leukemia\/lymphoma virus type i antibodies, dna, and protein in patients with polymyositis"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael P.","family":"Sherman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnikant M.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela E. 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