{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:05:17Z","timestamp":1765728317697},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3814,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1995,7]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To determine the prevalence and clinical significance of anti\u2010pyruvate dehydrogenase complex (anti\u2010PDC) antibodies in systemic sclerosis (SSc).<\/jats:p>Methods<\/jats:italic>. Serum samples from patients with limited cutaneous SSc (n = 81) or diffuse cutaneous SSc (n = 63) were examined for anti\u2010PDC antibodies by enzyme\u2010linked immunosorbent assay (ELISA) and immunoblotting.<\/jats:p>Results<\/jats:italic>. IgG\u2010 and\/or IgM\u2010isotype anti\u2010PDC antibodies were demonstrated by ELISA in 26 of 144 patients with SSc (18%). By immunoblotting, 19 patients had IgG anti\u2010PDC antibodies. Among these patients with IgG anti\u2010PDC antibodies, antibody to the E1\u03b1 subunit was significantly associated with the presence of laboratory abnormalities typical of primary biliary cirrhosis (PBC).<\/jats:p>Conclusion<\/jats:italic>. Antibody to the E1\u03b1 subunit of PDC may be a serologic indicator for the development of PBC in patients with SSc.<\/jats:p>","DOI":"10.1002\/art.1780380715","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T02:04:37Z","timestamp":1171505077000},"page":"985-989","source":"Crossref","is-referenced-by-count":18,"title":["Autoantibodies to pyruvate dehydrogenase complex in patients with systemic sclerosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Manabu","family":"Fujimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Ihn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)80033-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918090"},{"key":"e_1_2_1_4_2","first-page":"68","article-title":"Precipitating autoantibodies to mitochondrial proteins in progressive systemic sclerosis","volume":"58","author":"Gupta RC","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310310"},{"key":"e_1_2_1_6_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets, and pathogenesis","volume":"15","author":"Le Roy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360815"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.1.42"},{"key":"e_1_2_1_10_2","first-page":"75","article-title":"Primary biliary cirrhosis and the CREST syndrome: a report of 22 cases","volume":"62","author":"Powell FC","year":"1987","journal-title":"Q J Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.10.3525"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090110"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/cs0770365","article-title":"The E1\u03b1 and \u03b2 subunits of pyruvate dehydrogenase complex are M2 \u2018d\u2019 and M2 \u2018e\u2019 autoantigens in primary biliary cirrhosis","volume":"77","author":"Fussay SPM","year":"1989","journal-title":"Clin Sci"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070126"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100402"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4049\/jimmunol.144.5.1671","article-title":"Primary biliary cirrhosis: inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1\u03b1, a non\u2010lipoic acid containing mitochondrial enzyme","volume":"144","author":"Fregeau DR","year":"1990","journal-title":"J Immunol"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780380715","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780380715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:55:38Z","timestamp":1700765738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780380715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/art.1780380715"],"URL":"https:\/\/doi.org\/10.1002\/art.1780380715","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}