{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:06Z","timestamp":1760188866210},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3814,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of cirrhosis developing in a man who was heterozygous for \u03b1<jats:sub>1<\/jats:sub>\u2010antitrypsin deficiency and who was receiving methotrexate for severe rheumatoid arthritis. The \u03b1<jats:sub>1<\/jats:sub>\u2010antitrypsin phenotype PiMZ has been associated with cryptogenic cirrhosis. Our patient had no biochemical or histologic evidence of chronic liver disease during the first year of receiving methotrexate. We postulate that the PiMZ state may result in enhanced susceptibility to methotrexate\u2010induced hepatic toxicity and should be screened for if liver function abnormalities occur during methotrexate therapy.<\/jats:p>","DOI":"10.1002\/art.1780380719","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T02:04:37Z","timestamp":1171505077000},"page":"1014-1018","source":"Crossref","is-referenced-by-count":7,"title":["End\u2010stage liver disease developing with the use of methotrexate in heterozygous \u03b1<sub>1<\/sub>\u2010antitrypsin deficiency"],"prefix":"10.1002","volume":"38","author":[{"given":"Robert J.","family":"Hilsden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan J.","family":"Urbanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Swain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370304"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503283121303"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350202"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351003"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)80237-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-418"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(05)80060-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360307"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.50.584.362"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1975.tb19535.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198103053041001"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509088831"},{"key":"e_1_2_1_15_2","first-page":"49","article-title":"Epidemiology of hepatitis C","volume":"263","author":"Stevens CE","year":"1990","journal-title":"JAMA"},{"key":"e_1_2_1_16_2","first-page":"317","article-title":"Inactivated hepatitis B virus vaccine","volume":"31","author":"Centers for Disease Control","year":"1982","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780380719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780380719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:56:05Z","timestamp":1700765765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780380719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/art.1780380719"],"URL":"https:\/\/doi.org\/10.1002\/art.1780380719","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}