{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:11:32Z","timestamp":1791072692151,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3783,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To measure serum levels of matrix metalloproteinase\u20131 (MMP\u20101), matrix metalloproteinase\u20133 (MMP\u20103), and tissue inhibitor of MMP\u20131 (TIMP\u20101) in patients with rheumatoid arthritis (RA) and in agematched control subjects, and to determine how these correlate with serum levels of antigenic keratan sulfate (KS) and other biochemical and clinical indicators of disease activity.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Immunoassays were used to measure levels of MMP\u20101, MMP\u20103, TIMP\u20101, and antigenic KS. Radiologic and functional joint scores were based upon Steinbrocker's criteria. Erythrocyte sedimentation rates (ESR) and levels of C\u2010reactive proteins (CRP) were measured.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. In RA patients, levels of MMP\u20103 and TIMP\u20101 were significantly increased, and strongly correlated with the ESR and CRP levels but not with radiologic or functional joint scores. Levels of antigenic KS were significantly lower in RA patients and correlated negatively with systemic parameters of inflammation and serum levels of TIMP\u20101.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>. The increase in serum levels of MMP\u20103 and TIMP\u20101 appears to reflect systemic inflammation in RA. The inverse correlation between serum levels of TIMP\u20101 and antigenic KS suggests that an upregulation of TIMP\u20101 synthesis might be responsible for the apparent suppression of cartilage aggrecan catabolism in patients with severe inflammatory changes.<\/jats:p>","DOI":"10.1002\/art.1780380803","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T02:03:49Z","timestamp":1171505029000},"page":"1031-1039","source":"Crossref","is-referenced-by-count":83,"title":["Levels of circulating collagenase, stromelysin\u20101, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis: relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation"],"prefix":"10.1002","volume":"38","author":[{"given":"Daniel\u2010Henri","family":"Manicourt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken'ichi","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene j.\u2010 M. 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