{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:39:19Z","timestamp":1790177959938,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3752,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To analyze changes in functional status and the factors contributing to disability in a national inception cohort of 257 patients with polymyositis\/dermatomyositis (PM\/DM).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Data were gathered from patients' self\u2010reports on questionnaires: one concerning disease\u2010 and treatment\u2010related complications, and the other concerning disability, as reflected by a disability index (DI) derived from the Health Assessment Questionnaire (HAQ).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Based on certain characteristics that differentiated disability patterns, 3 groups of patients were identified. Group 1 patients (n = 153) were \u226560 years old and never had avascular necrosis (AVN) or a vertebral compression fracture (CF), Group 2 patients were &gt;60 and never had AVN or a vertebral CF, and Group 3 patients reported AVN or a vertebral CF irrespective of age. As measured by the HAQ DI, disability increased very gradually over time in Group 1 patients and more rapidly in Group 2 and Group 3 patients. The increase in disability in patients experiencing AVN was greater than that in patients with similar pre\u2010AVN disease characteristics who did not develop AVN (<jats:italic>P<\/jats:italic> = 0.003).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. In this prospective study of disease course and iatrogenic factors related to functional disability in PM\/DM, the HAQ DI increased with disease duration. Corticosteroid\u2010related morbidity, as reflected by the development of AVN or CF, significantly contributed to patient\u2010reported functional disability.<\/jats:p>","DOI":"10.1002\/art.1780380907","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T02:03:14Z","timestamp":1171504994000},"page":"1218-1224","source":"Crossref","is-referenced-by-count":71,"title":["A longitudinal study of functional disability in a national cohort of patients with polymyositis\/dermatomyositis"],"prefix":"10.1002","volume":"38","author":[{"given":"Ann E.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"jr","given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester V.","family":"Oddis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.182.1.1727285"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_1_4_2","first-page":"1218","article-title":"Predisposing factors in polymyositis\u2010dermatomyositis: results of a nationwide survey","volume":"16","author":"Lyons MG","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","first-page":"1329","article-title":"Incidence of polymyositis\u2013dermatomyositis: a 20\u2010year study of hospital diagnosed cases in Allegheny County, PA 1963\u20131982","volume":"17","author":"Oddis CV","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199111000-00002"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90148-I"},{"key":"e_1_2_1_8_2","first-page":"643","article-title":"Strength in polymyositis and dermatomyositis: best outcome in patients treated early","volume":"21","author":"Fafalak RG","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.1.23"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0307-742X(21)00488-4","article-title":"Cardiac abnormalities in inflammatory myopathy","volume":"10","author":"Askari AD","year":"1984","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90344-3"},{"key":"e_1_2_1_12_2","first-page":"1140","article-title":"Dermatopolymyositis and other connective tissue disease: a review of 105 cases","volume":"12","author":"Tymms KE","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","first-page":"494","article-title":"Polyarticular disability: a functional assessment","volume":"58","author":"Convery FR","year":"1977","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_1_14_2","volume-title":"Polymyositis and Dermatomyositis","author":"Hicks JE","year":"1988"},{"issue":"5","key":"e_1_2_1_15_2","first-page":"R9","article-title":"Comparison of manual muscle test and functional assessment to timed functional tests in patients with polymyositis (abstract)","volume":"35","author":"Hicks JE","year":"1992","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199205213262102"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(94)90084-1"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780380907","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780380907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:19:01Z","timestamp":1700767141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780380907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1002\/art.1780380907"],"URL":"https:\/\/doi.org\/10.1002\/art.1780380907","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}