{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:31:09Z","timestamp":1761647469997},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3752,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1995,9]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To compare hematologic and cyto\u2010fluorographic features in Feltyapos;s syndrome (FS) patients with and without the large granular lymphocyte (LGL) syndrome.<\/jats:p>Methods<\/jats:italic>. Peripheral blood cells from FS patients and from 2 control groups (rheumatoid arthritis [RA] patients and subjects without symptoms of a rheumatic disease) were analyzed by hematologic and cytofluorographic techniques. A separate assessment of disease activity was performed.<\/jats:p>Results.<\/jats:italic> FS patients had reduced lymphocyte and platelet counts, with a parallel reduction in lymphocyte subsets examined. CD4 counts were reduced in all FS patients, including those with the LGL syndrome. Disease activity was lower in FS patients than in RA control patients. Treatment was similar in all patient groups. No direct association was seen between LGL numbers and duration of RA or neutrophil counts in RA groups.<\/jats:p>Conclusion.<\/jats:italic> Hematologic abnormalities in FS extend beyond neutropenia. Although similarities were seen between FS patients and FS patients with the LGL syndrome (e.g., CD4 lymphopenia), evidence for a gradation from FS to the LGL syndrome was not seen, thus favoring the hypothesis that a \u201ctransforming event\u201d is required.<\/jats:p>","DOI":"10.1002\/art.1780380913","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T02:03:14Z","timestamp":1171504994000},"page":"1252-1259","source":"Crossref","is-referenced-by-count":10,"title":["Hematologic and cytofluorographic analysis of patients with feltyapos;s syndrome a hypothesis that a discrete event leads to large granular lymphocyte expansions in this condition"],"prefix":"10.1002","volume":"38","author":[{"given":"S. J.","family":"Bowman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Corrigall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Panayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Lanchbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199069020-00001"},{"key":"e_1_2_1_3_2","first-page":"1058","article-title":"Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome","volume":"19","author":"Meliconi R","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350505"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb02271.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211"},{"key":"e_1_2_1_7_2","first-page":"353","article-title":"The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T\u2010cell and NK\u2010cell subsets in human blood","volume":"59","author":"Ligthart GJ","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_1_9_2","first-page":"521","article-title":"Disease activity in rheumatoid arthritis: preliminary report of the Consensus Study Group of the European Workshop for Rheumatology Research","volume":"10","author":"Scott DL","year":"1992","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_1_11_2","first-page":"156","article-title":"Felty's syndrome: an analytical study","volume":"141","author":"Spivak JL","year":"1977","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.3.191"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370909"},{"key":"e_1_2_1_14_2","unstructured":"HowellWM LeungST JonesDB NakshabendiI HallMA LanchburyJS CiclitiraPJ WrightDH: HLA\u2010DRB DQA and DQB polymorphism in celiac disease and enteropathy\u2010associated T\u2010cell lymphoma: common features and additional risk factors for malignancy.Hum Immunol(in press)"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.4.357"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90208-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/30.3.217"},{"key":"e_1_2_1_18_2","first-page":"904","article-title":"T cell unresponsiveness in lepromatous leprosy","volume":"20","author":"Kamradt T","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360506"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1994.1009"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780380913","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780380913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:17:43Z","timestamp":1700767063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780380913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1002\/art.1780380913"],"URL":"https:\/\/doi.org\/10.1002\/art.1780380913","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}