{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:47:18Z","timestamp":1768081638939,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3722,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To investigate the pathogenetic role of antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis (WG).<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> BALB\/c mice were immunized with human IgG ANCA from a patient with WG. Control mice were immunized with normal human IgG. Levels of mouse ANCA and other autoantibodies were determined. Mouse ANCA were tested for their ability to induce adhesion and respiratory burst of neutrophils. The mouse lungs and kidneys were examined for the development of vasculitis.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Mice immunized with human ANCA developed anti\u2010human ANCA and anti\u2013anti\u2010human ANCA (mouse ANCA), while the controls did not develop these antibodies. Mouse ANCA were capable of inducing adhesion of neutrophils to fibronectin and activating the respiratory burst in neutrophils. Moreover, the mice that were immunized with human ANCA developed perivascular mononuclear cell infiltrates in the lungs, suggesting vasculitis.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The results suggest a pathogenic role of ANCA in WG, and may imply that activation of neutrophils is the initiating event in the development of vasculitis in WG.<\/jats:p>","DOI":"10.1002\/art.1780381004","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:55:12Z","timestamp":1171504512000},"page":"1375-1381","source":"Crossref","is-referenced-by-count":47,"title":["Characterization of biologically active antineutrophil cytoplasmic antibodies induced in mice:pathogenetic role in experimental vasculitis"],"prefix":"10.1002","volume":"38","author":[{"given":"Yaron","family":"Tomer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Gilburd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miri","family":"Blank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Lider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Hershkoviz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perina","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Zigelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piere\u2010Luigi","family":"Meroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Wiik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"191","article-title":"Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis","volume":"11","author":"Wiik A","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb03345.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-857X(21)00163-0","article-title":"Do antineutrophil cytoplasmic autoantibodies cause Wegener's granulomatosis and other forms of necrotizing vasculitis","volume":"19","author":"Jennette JC","year":"1993","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1096\/fasebj.4.9.2140806","article-title":"Pathogenic idiotypes of autoantibodies in autoimmunity: lessons from a new experimental model of SLE","volume":"4","author":"Shoenfeld Y","year":"1990","journal-title":"FASEB J"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.1.52"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302243080802"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916939309010644"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01541171"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.1.59"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.52"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90364-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.4049\/jimmunol.151.12.7260","article-title":"Induction of lupus\u2010associated autoantibodies by immunization with naive and recombinant Ig polypeptides expressing a cross\u2010reactive idiotype 4B4","volume":"151","author":"Dang H","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9182-2_69"},{"key":"e_1_2_1_15_2","first-page":"46","article-title":"Identification of the \u201cANCA\u2010antigen\u201d as a novel myeloid lysosomal serine protease","volume":"97","author":"Goldschmeding R","year":"1989","journal-title":"APMIS Suppl"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.15.8001742"}],"container-title":["Arthritis &amp; 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