{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:42:26Z","timestamp":1788817346337,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3691,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To test the hypothesis that the calcium antagonist diltiazem is effective in the treatment of calcinosis.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Diltiazem, 240\u2013480 mg\/day, was given to 4 patients with idiopathic or CREST\u2010related (calcinosis, Raynaud'S phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) calcinosis for 1\u201312 years. Serial radiographs of the affected areas, using identical technique, and clinical evaluations were obtained. A fifth patient, who did not tolerate diltiazem, received verapamil, 120 mg\/day for 18 months.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> All patients taking diltiazem had a reduction or disappearance of the calcific lesions, with striking clinical improvement. One patient'S case was followed for 12 years. The response to diltiazem during the first 5 years of treatment has been previously reported in detail; however, over 7 years of additional treatment, there was further reduction of the lesions. One patient developed a large calcific lesion while receiving verapamil for hypertension, and after verapamil was replaced with diltiazem, there was a dramatic response. Verapamil was ineffective in the fifth patient, who did not tolerate diltiazem.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Long\u2010term treatment with diltiazem, but not verapamil, is effective in calcinosis.<\/jats:p>","DOI":"10.1002\/art.1780381117","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:46:32Z","timestamp":1171503992000},"page":"1646-1654","source":"Crossref","is-referenced-by-count":97,"title":["Treatment of calcinosis with diltiazem"],"prefix":"10.1002","volume":"38","author":[{"given":"Genaro M. 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