{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:27:13Z","timestamp":1790972833734,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3691,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To investigate the characteristics of HLA\u2010B27 that render susceptibility to seronegative spondylarthropathies.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Serologic HLA class I typing of Japanese patients with ankylosing spondylitis (AS), juvenile rheumatoid arthritis (JRA), and healthy controls, was performed. HLA\u2010B39 subtypes were determined by polymerase chain reaction\u2010sequence\u2010specific oligohy\u2010bridization.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. HLA\u2010B27 was present in 40 of 48 patients with AS (83%), and in only 1 of 210 healthy controls (0.5%). Three of 8 patients (37.5%) who were negative for HLA\u2010B27 were positive for HLA\u2010B39, which was significantly higher compared with the HLA\u2010B27\u2010negative controls (6.2% <jats:italic>P<\/jats:italic> = 0.01). Significant association with HLA\u2010B39 was also noted in the JRA patients (16.7%; <jats:italic>P<\/jats:italic> &lt; 0.01), especially in those patients with pauciarticular\u2010onset disease (33.3%; <jats:italic>P<\/jats:italic> &lt; 0.01). Ten of 13 HLA\u2010B39\u2010positive patients had subtype B<jats:sup>*<\/jats:sup>3901 and 3 had B<jats:sup>*<\/jats:sup>3902.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Because HLA\u2010B27 and HLA\u2010B39 share Glu at position 45 and Cys at position 67, both of which constitute components of the peptide\u2010anchoring B pocket, and because they possess similar peptide\u2010ligand motifs, our results may support either the role of the peptides presented by class I antigens or the importance of Cys at position 67, in the development of spondylarthropathies and pauciarticular\u2010onset JRA.<\/jats:p>","DOI":"10.1002\/art.1780381120","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:46:32Z","timestamp":1171503992000},"page":"1672-1677","source":"Crossref","is-referenced-by-count":106,"title":["Association of hla\u2010b39 with hla\u2010b27\u2010negative ankylosing spondylitis and pauciarticular juvenile rheumatoid arthritis in japanese patients"],"prefix":"10.1002","volume":"38","author":[{"given":"Akihiro","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushi","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayoshi","family":"Yoshinoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Juji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90512-D"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780301102"},{"key":"e_1_2_1_4_2","first-page":"453","article-title":"New 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