{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:58:04Z","timestamp":1791122284885,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":3661,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To quantify soluble Fas\/APO\u20101 (sFas\/APO\u20101 ) protein in the serum of patients with systemic lupus erythematosus (SLE) and juvenile rheumatoid arthritis (JRA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Soluble Fas\/APO\u20101 was quantified using a sandwich enzyme\u2010linked immunosorbent assay. Disease activity in SLE patients was assessed by the SLE Disease Activity Index.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Increased serum sFas\/APO\u20101 levels were observed in only 1 of the 27 SLE patients (4%) and 3 of the 10 JRA patients (30%).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Increased levels of sFas\/APO\u20101 occurred infrequently in SLE, and the levels were lower than 10 ng\/ml. Increased levels of sFas\/APO\u20101 are not specific for SLE. Soluble Fas\/APO\u20101 is unlikely to be of major pathogenetic significance in SLE.<\/jats:p>","DOI":"10.1002\/art.1780381205","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:46:09Z","timestamp":1171503969000},"page":"1735-1737","source":"Crossref","is-referenced-by-count":61,"title":["Levels of soluble fas\/APO\u20101 \/CD95 in systemic lupus erythematosus and juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"38","author":[{"given":"Eckart","family":"Knipping","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen B.","family":"Onel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J. A.","family":"Lehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mysler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith B.","family":"Elkon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2787530"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"e_1_2_1_4_2","first-page":"553","article-title":"Apoptosis in SLE: too little or too much","volume":"12","author":"Elkon KB","year":"1994","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117051"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7510905"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"issue":"2","key":"e_1_2_1_8_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1182\/blood.V85.6.1562.bloodjournal8561562","article-title":"Identification of soluble APO\u20101 in supernatants of human B and T cell lines and increased serum levels in B and T cell leukemias","volume":"85","author":"Knipping E","year":"1995","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90816-W"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/373438a0"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780381205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780381205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T06:29:44Z","timestamp":1700720984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780381205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["10.1002\/art.1780381205"],"URL":"https:\/\/doi.org\/10.1002\/art.1780381205","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}